ONE-POT SYNTHESIS OF ISOQUINUCLIDINE DERIVATIVES THROUGH MULTICOMPONENT AZA-DIELS-ALDER REACTIONS PROMOTED BY NIOBIUM PENTAETHOXIDE

Sacoman Torquato da Silva, Bruno Henrique [UNESP]; Luiz Carlos da Silva-Filho, Lucas Michelao Martinsand [UNESP]

ONE-POT SYNTHESIS OF ISOQUINUCLIDINE DERIVATIVES THROUGH MULTICOMPONENT AZA-DIELS-ALDER REACTIONS PROMOTED BY NIOBIUM PENTAETHOXIDE

Date

2015-01-01

Authors

Sacoman Torquato da Silva, Bruno Henrique

Luiz Carlos da Silva-Filho, Lucas Michelao Martinsand

Publisher

Raman Publ

Type

Article

Access right

Acesso restrito

Abstract

The bicyclic isoquinuclidine system can be found in many natural products and has several pharmacological properties. In this paper is described an one-pot sysnthesis of Isoquinuclidine derivatives through multicomponent aza-Diels-Alder reactions between aniline derivatives, benzaldehyde and 2-cyclohexenone, promoted by niobium pentaethoxide under mild conditions, affording the expected products in high yields.