Logotipo do repositório
 

Publicação:
Impairment on sperm quality and fertility of adult rats after antiandrogen exposure during prepuberty

Página do item simplificado
dc.contributor.authorPerobelli, Juliana Elaine [UNESP]
dc.contributor.authorAlves, Thais Regina [UNESP]
dc.contributor.authorde Toledo, Fabiola Choqueta [UNESP]
dc.contributor.authorFernandez, Carla Dal Bianco [UNESP]
dc.contributor.authorAnselmo-Franci, Janete A.
dc.contributor.authorKlinefelter, Gary R.
dc.contributor.authorKempinas, Wilma de Grava [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T13:52:03Z
dc.date.available2014-05-20T13:52:03Z
dc.date.issued2012-06-01
dc.description.abstractThis study evaluated the effects of antiandrogen exposure during the prepubertal period on reproductive development and reproductive competence in adults. Male rats were divided into two groups: flutamide, receiving 25 mg/kg/day of flutamide by oral gavage and control, receiving vehicle daily. Dosing continued from PND 21 to 44, and animals were killed on PND 50 or PND 75-80. The epididymis, prostate, vas deferens and seminal vesicle weights were lower in Flutamide group on PND 50, while on PND 80 only seminal vesicle weight was reduced. Fertility assessed by IUI revealed a decrease in the fertility potential in the flutamide-treated adults. Flutamide accelerated sperm transit time through the epididymis, impairing sperm motility and storage. A quantitative analysis of the cauda sperm membrane proteome revealed a few significant changes in protein expression. Thus, exposure to flutamide during the prepubertal period compromises the function of the epididymis along with epididymal sperm quality at adulthood. (C) 2011 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, UNESP, Inst Biosci, Dept Morphol, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, UNICAMP, Inst Biol, Grad Program Cellular & Struct Biol, Campinas, SP, Brazil
dc.description.affiliationUniv São Paulo, Sch Dent, Dept Morphol Stomatol & Physiol, BR-14049 Ribeirao Preto, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Inst Biosci, Dept Morphol, BR-18618970 Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 07/59079-4
dc.description.sponsorshipIdCNPq: 501339/2010-8
dc.format.extent308-315
dc.identifierhttp://dx.doi.org/10.1016/j.reprotox.2011.12.011
dc.identifier.citationReproductive Toxicology. Oxford: Pergamon-Elsevier B.V. Ltd, v. 33, n. 3, p. 308-315, 2012.
dc.identifier.doi10.1016/j.reprotox.2011.12.011
dc.identifier.issn0890-6238
dc.identifier.lattes6326450271169741
dc.identifier.urihttp://hdl.handle.net/11449/18596
dc.identifier.wosWOS:000303361200006
dc.language.isoeng
dc.publisherPergamon-Elsevier B.V. Ltd
dc.relation.ispartofReproductive Toxicology
dc.relation.ispartofjcr2.580
dc.relation.ispartofsjr0,846
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAntiandrogenen
dc.subjectRaten
dc.subjectEpididymisen
dc.subjectPrepubertyen
dc.subjectSperm qualityen
dc.subjectFertilityen
dc.subjectProteomicsen
dc.titleImpairment on sperm quality and fertility of adult rats after antiandrogen exposure during prepubertyen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderPergamon-Elsevier B.V. Ltd
dspace.entity.typePublication
unesp.author.lattes6326450271169741
unesp.author.orcid0000-0002-6480-1187[5]
unesp.author.orcid0000-0002-2112-5123[7]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.departmentMorfologia - IBBpt

Arquivos

Licença do Pacote

Agora exibindo 1 - 2 de 2
Imagem de Miniatura
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Imagem de Miniatura
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:

Coleções

Botucatu - IBB - Instituto de Biociências