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Insight into Recent Drug Discoveries against Trypanosomatids and Plasmodium spp Parasites: New Metal-based Compounds

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dc.contributor.authorScarim, Cauê Benito [UNESP]
dc.contributor.authorde Farias, Renan Lira [UNESP]
dc.contributor.authorChiba, Diego Eidy [UNESP]
dc.contributor.authorChin, Chung Man [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUnion of the Colleges of the Great Lakes (UNILAGO)
dc.date.accessioned2023-03-02T00:29:05Z
dc.date.available2023-03-02T00:29:05Z
dc.date.issued2022-04-01
dc.description.abstractScaffolds of metal-based compounds can act as pharmacophore groups in several ligands to treat various diseases, including tropical infectious diseases (TID). In this review article, we investigate the contribution of these moieties to medicinal inorganic chemistry in the last seven years against TID, including American trypanosomiasis (Chagas disease), human African trypanosomiasis (HAT, sleeping sickness), leishmania, and malaria. The most potent metal-based complexes are displayed and highlighted in figures, tables and graphics; according to their pharmacological activities (IC50 > 10µM) against Trypanosomatids and Plasmodium spp parasites. We highlight the current progresses and viewpoints of these metal-based complexes, with a specific focus on drug discovery.en
dc.description.affiliationSao Paulo State University(UNESP) School of Pharmaceutical Sciences, SP
dc.description.affiliationLapdesf-Laboratory of Research and Development of Drugs Sao Paulo State University (UNESP) School of Pharmaceutical Sciences, SP
dc.description.affiliationSao Paulo State University(UNESP) Institute of Chemistry, SP
dc.description.affiliationAdvance Research Center in Medicine Union of the Colleges of the Great Lakes (UNILAGO), SP
dc.description.affiliationUnespSao Paulo State University(UNESP) School of Pharmaceutical Sciences, SP
dc.description.affiliationUnespLapdesf-Laboratory of Research and Development of Drugs Sao Paulo State University (UNESP) School of Pharmaceutical Sciences, SP
dc.description.affiliationUnespSao Paulo State University(UNESP) Institute of Chemistry, SP
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdCAPES: 001
dc.description.sponsorshipIdFAPESP: 2016/10847-9
dc.format.extent2334-2381
dc.identifierhttp://dx.doi.org/10.2174/0929867328666210917114912
dc.identifier.citationCurrent Medicinal Chemistry, v. 29, n. 13, p. 2334-2381, 2022.
dc.identifier.doi10.2174/0929867328666210917114912
dc.identifier.issn1875-533X
dc.identifier.issn0929-8673
dc.identifier.scopus2-s2.0-85129771182
dc.identifier.urihttp://hdl.handle.net/11449/241818
dc.language.isoeng
dc.relation.ispartofCurrent Medicinal Chemistry
dc.sourceScopus
dc.subjectLeishmania
dc.subjectMetal-based drugs
dc.subjectnew drugs
dc.subjectPlasmodium ssp
dc.subjectT. brucei
dc.subjectT. cruzi
dc.titleInsight into Recent Drug Discoveries against Trypanosomatids and Plasmodium spp Parasites: New Metal-based Compoundsen
dc.typeResenhapt
dspace.entity.typePublication
relation.isDepartmentOfPublicatione214da1b-9929-4ae9-b8fd-655e9bfeda4b
relation.isDepartmentOfPublication.latestForDiscoverye214da1b-9929-4ae9-b8fd-655e9bfeda4b
unesp.departmentFármacos e Medicamentos - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas