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Synthesis of Analogues of Thyroid Hormones: Nuclear Receptor Modulators

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dc.contributor.authorCastro, Guilherme Vieira de
dc.contributor.authorRomero Rocha, Carlos Murilo
dc.contributor.authorSanches, Vitor Lacerda
dc.contributor.authorZana Ribeiro, Pedro H.
dc.contributor.authorDonate, Paulo Marcos
dc.contributor.authorlaurentiz, Rosangela da Silva de [UNESP]
dc.contributor.authorPolikarpov, Igor
dc.contributor.authorSairre, Mirela I.
dc.contributor.institutionUniversidade Federal do ABC (UFABC)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-11-26T16:05:25Z
dc.date.available2018-11-26T16:05:25Z
dc.date.issued2015-07-01
dc.description.abstractThyroid hormones are essential for the development and differentiation of all cells of the human body. This work reports the synthesis of some synthetic structural analogues of thyroid hormones, which may be modulators of the thyroid hormone receptor. The known compounds GC-1 (Sobetirome) and CG-24 were successfully prepared and two novel analogous molecules were also synthesized by a new and efficient synthetic methodology.en
dc.description.affiliationUniv Fed ABC, Ctr Ciencias Nat & Humanas, Rua Santa Adelia 166, BR-09210170 Santo Andre, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, BR-14040901 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Fac Engn, Dept Fis & Quim, BR-15385000 Ilha Solteira, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Fis Sao Carlos, Dept Fis & Informat, BR-13566590 Sao Carlos, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Engn, Dept Fis & Quim, BR-15385000 Ilha Solteira, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent282-291
dc.identifierhttp://dx.doi.org/10.17807/orbital.v7i3.739
dc.identifier.citationOrbital-the Electronic Journal Of Chemistry. Campo Grande: Univ Federal Mato Grosso Sul, Dept Quimica, v. 7, n. 3, p. 282-291, 2015.
dc.identifier.doi10.17807/orbital.v7i3.739
dc.identifier.fileWOS000219762300011.pdf
dc.identifier.issn1984-6428
dc.identifier.lattes7989837727910759
dc.identifier.orcid0000-0002-5240-4870
dc.identifier.urihttp://hdl.handle.net/11449/160636
dc.identifier.wosWOS:000219762300011
dc.language.isoeng
dc.publisherUniv Federal Mato Grosso Sul, Dept Quimica
dc.relation.ispartofOrbital-the Electronic Journal Of Chemistry
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectthyroid hormones
dc.subjectnuclear receptor
dc.subjectligands
dc.subjectsynthesis
dc.titleSynthesis of Analogues of Thyroid Hormones: Nuclear Receptor Modulatorsen
dc.typeArtigo
dcterms.rightsHolderUniv Federal Mato Grosso Sul, Dept Quimica
dspace.entity.typePublication
unesp.author.lattes7989837727910759[6]
unesp.author.orcid0000-0002-1404-5328[5]
unesp.author.orcid0000-0002-5240-4870[6]
unesp.departmentFísica e Química - FEISpt

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Ilha Solteira - FEIS - Faculdade de Engenharia