Publicação: Fetal developmental programing: insights from human studies and experimental models
Carregando...
Data
Orientador
Coorientador
Pós-graduação
Curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Editor
Tipo
Resenha
Direito de acesso
Acesso aberto
Resumo
Background: Environmental factors, particularly nutrition during pregnancy and early life can influence the risk of chronic diseases in later life. The underlying mechanism, termed “programing”, postulates that an environmental stimulus during a critical window of time, early in life, has a permanent effect on subsequent structure and function of the organism. Objective: In this study we review the concept of fetal programing on chronic diseases and the proposed hypotheses for the association between early development and later disease, including epigenetic variation. We concentrate on specific aspects of maternal nutrition, particularly under-nutrition and over-nutrition, in humans and animal models. Conclusion: An adequate maternal nutrition during pregnancy is crucial for the health outcome of the offspring at adulthood.
Descrição
Palavras-chave
Developing countries, epigenetic process, fetal developmental programing, maternal over-nutrition, maternal under-nutrition
Idioma
Inglês
Como citar
Journal of Maternal-Fetal and Neonatal Medicine, v. 30, n. 6, p. 722-728, 2017.
