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Thiazole, thio and semicarbazone derivatives against tropical infective diseases: Chagas disease, human African trypanosomiasis (HAT), leishmaniasis, and malaria

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dc.contributor.authorScarim, Cauê Benito [UNESP]
dc.contributor.authorJornada, Daniela Hartmann [UNESP]
dc.contributor.authorMachado, Marcella Gabrielle Mendes [UNESP]
dc.contributor.authorFerreira, Carla Maria Riberio [UNESP]
dc.contributor.authordos Santos, Jean Leandro [UNESP]
dc.contributor.authorChung, Man Chin [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2019-10-06T15:24:45Z
dc.date.available2019-10-06T15:24:45Z
dc.date.issued2019-01-15
dc.description.abstractThiazole, thiosemicarbazone and semicarbazone moieties are privileged scaffolds (acting as primary pharmacophores) in many compounds that are useful to treat several diseases, mainly tropical infectious diseases. In this review article, we critically analyzed the contribution of these scaffolds to medicinal chemistry in the last five years, focusing on tropical infectious diseases, such as Chagas disease, human African trypanosomiasis (HAT), leishmaniasis, and malaria. We also present perspectives for their use in drug design in order to contribute to the development of new drugs.en
dc.description.affiliationSão Paulo State University (UNESP) School of Pharmaceutical Sciences
dc.description.affiliationUnespSão Paulo State University (UNESP) School of Pharmaceutical Sciences
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: FAPESP - 2016/10847-9
dc.format.extent378-395
dc.identifierhttp://dx.doi.org/10.1016/j.ejmech.2018.11.013
dc.identifier.citationEuropean Journal of Medicinal Chemistry, v. 162, p. 378-395.
dc.identifier.doi10.1016/j.ejmech.2018.11.013
dc.identifier.issn1768-3254
dc.identifier.issn0223-5234
dc.identifier.lattes9734333607975413
dc.identifier.orcid0000-0003-4141-0455
dc.identifier.scopus2-s2.0-85056663289
dc.identifier.urihttp://hdl.handle.net/11449/187074
dc.language.isoeng
dc.relation.ispartofEuropean Journal of Medicinal Chemistry
dc.rights.accessRightsAcesso abertopt
dc.sourceScopus
dc.subjectChagas disease
dc.subjectDrug development
dc.subjectNew drugs
dc.subjectSemicarbazone
dc.subjectT. cruzi
dc.subjectThiazole
dc.subjectThiosemicarbazone
dc.titleThiazole, thio and semicarbazone derivatives against tropical infective diseases: Chagas disease, human African trypanosomiasis (HAT), leishmaniasis, and malariaen
dc.typeResenhapt
dspace.entity.typePublication
relation.isOrgUnitOfPublication95697b0b-8977-4af6-88d5-c29c80b5ee92
relation.isOrgUnitOfPublication.latestForDiscovery95697b0b-8977-4af6-88d5-c29c80b5ee92
unesp.author.lattes9734333607975413[6]
unesp.author.orcid0000-0003-4141-0455[6]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas