Logotipo do repositório
 

Publicação:
Lack of inhibitory effect of zinc on prolactin secretion induced by cimetidine

Página do item simplificado
dc.contributor.authorCastro, A. V. B. [UNESP]
dc.contributor.authorMendonça, B. B.
dc.contributor.authorBloise, W.
dc.contributor.authorShuhama, T.
dc.contributor.authorBrandão-Neto, J.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal do Rio Grande do Norte (UFRN)
dc.date.accessioned2014-05-27T11:21:20Z
dc.date.available2014-05-27T11:21:20Z
dc.date.issued2005-06-01
dc.description.abstractThe dopaminergic, serotoninergic and GABA-ergic systems are closely involved in PRL secretion, as well as thyrotropin-releasing hormone. There is some evidence that zinc interacts with some of these neuroamines and neuropeptides. The histamine H2-receptor cimetidine stimulates PRL secretion rapidly following an intravenous injection in man. In this sense, we investigated probable inhibitory effect of zinc on prolactin secretion following cimetidine injection (300 mg). Therefore, we studied five healthy adult men, before and after oral zinc administration (25 mg elemental zinc) during three consecutive months. The results did not demonstrate any inhibitory effect of zinc on prolactin secretion. So, we originally concluded that zinc did not interact with dopamine, serotonine, gamma-aminobutyric acid and the thyrotropin-releasing hormone in humans. In addition, the intravenous administration of cimetidine did not change the serum zinc profile. © 2005 Dustri-Vertag Dr. K. Feistle.en
dc.description.affiliationUnidade de Endocrinologia e Metabologia Faculdade de Medicina UNESP, Botucatu - São Paulo
dc.description.affiliationUnidade de Endocrinologia Faculdade de Medicina USP, São Paulo - SP
dc.description.affiliationLaboratório de Química Analítica Faculdade de Ciências Farmacêuticas USP, Ribeirao Preto - Sao Paulo
dc.description.affiliationUnidade de Endocrinologia e Metabologia Centro de Ciências da Saúde UFRN, Natal - RN, CEP: 59 010-180
dc.description.affiliationUnespUnidade de Endocrinologia e Metabologia Faculdade de Medicina UNESP, Botucatu - São Paulo
dc.format.extent133-138
dc.identifierhttp://www.dustri.com/nc/article-response-page.html?artId=2167
dc.identifier.citationTrace Elements and Electrolytes, v. 22, n. 2, p. 133-138, 2005.
dc.identifier.issn0946-2104
dc.identifier.scopus2-s2.0-18344364514
dc.identifier.urihttp://hdl.handle.net/11449/68263
dc.identifier.wosWOS:000228753700007
dc.language.isoeng
dc.relation.ispartofTrace Elements and Electrolytes
dc.relation.ispartofjcr0.381
dc.relation.ispartofsjr0,124
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectCimetidine tolerance test
dc.subjectHealthy men
dc.subjectNeurotransmitters
dc.subjectProlactin secretion
dc.subjectZinc tolerance test
dc.subject4 aminobutyric acid
dc.subjectcimetidine
dc.subjectdopamine
dc.subjecthistamine H2 receptor
dc.subjectprolactin
dc.subjectprotirelin
dc.subjectserotonin
dc.subjectzinc
dc.subjectadult
dc.subjectcontrolled study
dc.subjectcorrelation analysis
dc.subjectdiet supplementation
dc.subjectdopaminergic transmission
dc.subjectdrug effect
dc.subjectdrug mechanism
dc.subjecthistamine release
dc.subjecthormone action
dc.subjecthuman
dc.subjecthuman experiment
dc.subjectmale
dc.subjectnormal human
dc.subjectpriority journal
dc.subjectprolactin release
dc.subjectserotoninergic system
dc.subjectside effect
dc.subjectzinc blood level
dc.titleLack of inhibitory effect of zinc on prolactin secretion induced by cimetidineen
dc.typeArtigo
dcterms.licensehttp://www.dustri.com/nc/journals-in-english/mag/clinical-nephrology.html?mode=ai
dspace.entity.typePublication
unesp.author.orcid0000-0003-1762-1084[2]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
unesp.departmentClínica Médica - FMBpt

Arquivos

Coleções

Botucatu - FMB - Faculdade de Medicina