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DNA damage and nitric oxide synthesis in experimentally infected Balb/c mice with Trypanosoma cruzi

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dc.contributor.authorRibeiro, Daniel A. [UNESP]
dc.contributor.authorCalvi, Sueli Aparecida [UNESP]
dc.contributor.authorPicka, Mariele M. [UNESP]
dc.contributor.authorPersi, Eliana [UNESP]
dc.contributor.authorde Carvalho, Thaís B. [UNESP]
dc.contributor.authorCaetano, Priscila K. [UNESP]
dc.contributor.authorNagoshi, Lidiana R. [UNESP]
dc.contributor.authorLima, Carlos R.G. [UNESP]
dc.contributor.authorMachado, Jussara M. [UNESP]
dc.contributor.authorSalvadori, Daisy Maria Favero [UNESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:22:30Z
dc.date.available2014-05-27T11:22:30Z
dc.date.issued2007-07-01
dc.description.abstractThis study aimed to evaluate whether experimental Chagas disease in acute phase under benznidazole therapy can cause DNA damage in peripheral blood, liver, heart, and spleen cells or induce nitric oxide synthesis in spleen cells. Twenty Balb/c mice were distributed into four groups: control (non-infected animals); Trypanosoma cruzi infected; T. cruzi infected and submitted to benznidazole therapy; and only treated with benznidazole. The results obtained with the single cell gel (comet) assay showed that T. cruzi was able induce DNA damage in heart cells of both benznidazole treated or untreated infected mice. Similarly, T. cruzi infected animals showed an increase of DNA lesions in spleen cells. Regarding nitric oxide synthesis, statistically significant differences (p < 0.05) were observed in all experimental groups compared to negative control, the strongest effect observed in the T. cruzi infected group. Taken together, these results indicate that T. cruzi may increase the level of DNA damage in mice heart and spleen cells. Probably, nitric oxide plays an important role in DNA damaging whereas benznidazole was able to minimize induced T. cruzi genotoxic effects in spleen cells. © 2006 Elsevier Inc. All rights reserved.en
dc.description.affiliationDepartment Health Sciences Federal University of Sao Paulo UNIFESP, SP
dc.description.affiliationDepartment of Pathology Botucatu Medical School Sao Paulo State University, SP
dc.description.affiliationDepartment of Tropical Diseases and Image Diagnosis Botucatu Medical School Sao Paulo State University, SP
dc.description.affiliationUnespDepartment of Pathology Botucatu Medical School Sao Paulo State University, SP
dc.description.affiliationUnespDepartment of Tropical Diseases and Image Diagnosis Botucatu Medical School Sao Paulo State University, SP
dc.format.extent296-301
dc.identifierhttp://dx.doi.org/10.1016/j.exppara.2006.12.007
dc.identifier.citationExperimental Parasitology, v. 116, n. 3, p. 296-301, 2007.
dc.identifier.doi10.1016/j.exppara.2006.12.007
dc.identifier.issn0014-4894
dc.identifier.issn1090-2449
dc.identifier.lattes2179450022699059
dc.identifier.lattes5051118752980903
dc.identifier.scopus2-s2.0-34248211136
dc.identifier.urihttp://hdl.handle.net/11449/69733
dc.language.isoeng
dc.relation.ispartofExperimental Parasitology
dc.relation.ispartofjcr1.821
dc.relation.ispartofsjr0,635
dc.relation.ispartofsjr0,635
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectChagas disease
dc.subjectNitric oxide
dc.subjectSingle cell gel (comet) assay
dc.subjectTrypanosoma cruzi
dc.subjectbenznidazole
dc.subjectnitric oxide
dc.subjectacute phase response
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectcomet assay
dc.subjectcontrolled study
dc.subjectDNA damage
dc.subjectDNA strand breakage
dc.subjectexperimental infection
dc.subjectgenotoxicity
dc.subjectheart injury
dc.subjectmale
dc.subjectmouse
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectspleen injury
dc.subjectstatistical significance
dc.subjecttherapy effect
dc.subjecttreatment outcome
dc.subjectAnimals
dc.subjectBlood Cells
dc.subjectChagas Disease
dc.subjectDNA Damage
dc.subjectLiver
dc.subjectMale
dc.subjectMice
dc.subjectMice, Inbred BALB C
dc.subjectMyocardium
dc.subjectNeoplasms
dc.subjectNitric Oxide
dc.subjectNitroimidazoles
dc.subjectRandom Allocation
dc.subjectSpleen
dc.subjectTrypanocidal Agents
dc.subjectAnimalia
dc.subjectMus
dc.titleDNA damage and nitric oxide synthesis in experimentally infected Balb/c mice with Trypanosoma cruzien
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dspace.entity.typePublication
unesp.author.lattes2179450022699059
unesp.author.lattes5051118752980903
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
unesp.departmentDoenças Tropicais e Diagnósticos por Imagem - FMBpt
unesp.departmentPatologia - FMBpt

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Botucatu - FMB - Faculdade de Medicina