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Altered Ex Vivo Expression of Caspase 8, Caspase 9, and Bcl-2 Is Associated with T-Cell Hyporeactivity in Patients with Paracoccidioidomycosis

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dc.contributor.authorCacere, Camila R.
dc.contributor.authorMendes-Giannini, Maria José Soares [UNESP]
dc.contributor.authordo Valle, Antonio Carlos F.
dc.contributor.authorDuarte, Alberto J. S.
dc.contributor.authorBenard, Gil
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionFiocruz MS
dc.date.accessioned2014-05-20T13:23:51Z
dc.date.available2014-05-20T13:23:51Z
dc.date.issued2009-06-01
dc.description.abstractTo better understand the T-cell hyporesponsiveness of patients with paracoccidioidomycosis, we tested the hypothesis that the T cells were committed to apoptosis. We show here that T cells of patients with paracoccidioidomycosis overexpress caspase 9 and caspase 8 but express low Bcl-2 levels and that interleukin-2 was unable to revert the hyporesponsiveness. These data suggest that the T cells would in vivo be driven to a tolerant state and apoptosis.en
dc.description.affiliationUniv São Paulo, Sch Med, Lab Dermatol & Immunodeficiencies, BR-05403903 São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ, Fac Pharmaceut Sci, Dept Clin Pathol, São Paulo, Brazil
dc.description.affiliationFiocruz MS, Inst Pesquisa Evandro Chagas, BR-21045900 Rio de Janeiro, Brazil
dc.description.affiliationUniv São Paulo, Sch Med, Clin Hosp, Div Infect Dis,Syst Mycoses Outpatient Unit, BR-05403903 São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Fac Pharmaceut Sci, Dept Clin Pathol, São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 02/10893-8
dc.description.sponsorshipIdFAPESP: 02/07306-3
dc.format.extent953-955
dc.identifierhttp://dx.doi.org/10.1128/CVI.00071-09
dc.identifier.citationClinical and Vaccine Immunology. Washington: Amer Soc Microbiology, v. 16, n. 6, p. 953-955, 2009.
dc.identifier.dimensionspub.1038595789
dc.identifier.doi10.1128/CVI.00071-09
dc.identifier.fileWOS000266638900025.pdf
dc.identifier.issn1556-6811
dc.identifier.issn2379-5042
dc.identifier.issn1556-679x
dc.identifier.orcid0000-0002-8059-0826
dc.identifier.orcid0000-0003-0890-4525
dc.identifier.orcid0000-0002-5469-3602
dc.identifier.orcid0000-0002-8707-4904
dc.identifier.pmcidPMC2691056
dc.identifier.pmid19386797
dc.identifier.urihttp://hdl.handle.net/11449/7262
dc.identifier.wosWOS:000266638900025
dc.language.isoeng
dc.publisherAmer Soc Microbiology
dc.publisherAmerican Society for Microbiology
dc.relation.ispartofClinical and Vaccine Immunology
dc.relation.ispartofjcr2.872
dc.relation.ispartofsjr1,320
dc.rights.accessRightsAcesso abertopt
dc.sourceWeb of Science
dc.sourceDimensions
dc.titleAltered Ex Vivo Expression of Caspase 8, Caspase 9, and Bcl-2 Is Associated with T-Cell Hyporeactivity in Patients with Paracoccidioidomycosisen
dc.typeArtigopt
dcterms.licensehttp://journals.asm.org/site/misc/ASM_Author_Statement.xhtml
dcterms.rightsHolderAmer Soc Microbiology
dspace.entity.typePublication
relation.isDepartmentOfPublicationa83d26d6-5383-42e4-bb3c-2678a6ddc144
relation.isDepartmentOfPublication.latestForDiscoverya83d26d6-5383-42e4-bb3c-2678a6ddc144
relation.isOrgUnitOfPublication95697b0b-8977-4af6-88d5-c29c80b5ee92
relation.isOrgUnitOfPublication.latestForDiscovery95697b0b-8977-4af6-88d5-c29c80b5ee92
unesp.author.orcid0000-0002-8059-0826[2]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentAnálises Clínicas - FCFpt

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