Young ovine death during hyperimmunization: crotalic envenomation or copper toxicosis?
dc.contributor.author | Ferreira Júnior, Rui Seabra [UNESP] | |
dc.contributor.author | Nascimento, N. | |
dc.contributor.author | Couto, R. [UNESP] | |
dc.contributor.author | Alves, J. B. | |
dc.contributor.author | Meira, D. A. [UNESP] | |
dc.contributor.author | Barraviera, Benedito [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Instituto de Pesquisas Energéticas e Nucleares (IPEN) | |
dc.date.accessioned | 2014-05-20T13:34:31Z | |
dc.date.available | 2014-05-20T13:34:31Z | |
dc.date.issued | 2008-01-01 | |
dc.description.abstract | The unfavorable evolution of a young ovine during hyperimmunization process with Crotalus durissus terrificus venom was investigated in order to differentiate its origin between ophidic envenomation and copper toxicosis. Clinical, laboratory, necroscopic and histological exams as well as evaluation and measurement of heavy metals (copper) in the kidneys and in the liver were carried out. Blood counts revealed anemia and serological tests showed high levels of blood urea nitrogen, creatinine, aspartate aminotransferase, creatine phosphokinase, total bilirubin and indirect bilirubin; which indicates liver, kidney and skeletal muscle damages. At necropsy, the animal presented hepatopathy and nephropathy. Histological examination revealed renal and hepatic features that may imply copper intoxication. Copper levels were 237.8 mu g/g in the liver and 51.2 mu g/g in the kidneys. Although the amount of metal found in both organs was below the level that can cause death, according to the literature, anatomopathological signs were suggestive of copper intoxication. Therefore, the hypothesis of metal toxicosis during the hyperimmunization process became more consistent than the crotalic envenomation one. | en |
dc.description.affiliation | São Paulo State Univ, CEVAP, UNESP, Ctr Study Venoms & Venomous Anim, BR-18618000 Botucatu, SP, Brazil | |
dc.description.affiliation | São Paulo State Univ, UNESP, Botucatu Med Sch, Dept Trop Dis, BR-18618000 Botucatu, SP, Brazil | |
dc.description.affiliation | IPEN CNEN SP, Inst Nucl Energy Res, São Paulo, Brazil | |
dc.description.affiliation | São Paulo State Univ, UNESP, Clin Lab Vet, Vet Med & Anim Husb Sch, BR-18618000 Botucatu, SP, Brazil | |
dc.description.affiliationUnesp | São Paulo State Univ, CEVAP, UNESP, Ctr Study Venoms & Venomous Anim, BR-18618000 Botucatu, SP, Brazil | |
dc.description.affiliationUnesp | São Paulo State Univ, UNESP, Botucatu Med Sch, Dept Trop Dis, BR-18618000 Botucatu, SP, Brazil | |
dc.description.affiliationUnesp | São Paulo State Univ, UNESP, Clin Lab Vet, Vet Med & Anim Husb Sch, BR-18618000 Botucatu, SP, Brazil | |
dc.format.extent | 738-749 | |
dc.identifier | http://dx.doi.org/10.1590/S1678-91992008000400015 | |
dc.identifier.citation | Journal of Venomous Animals and Toxins Including Tropical Diseases. Botucatu: Cevap-unesp, v. 14, n. 4, p. 738-749, 2008. | |
dc.identifier.file | S1678-91992008000400015-en.pdf | |
dc.identifier.issn | 1678-9199 | |
dc.identifier.scielo | S1678-91992008000400015 | |
dc.identifier.uri | http://hdl.handle.net/11449/11843 | |
dc.identifier.wos | WOS:000267352500015 | |
dc.language.iso | eng | |
dc.publisher | Universidade Estadual Paulista (Unesp), Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP) | |
dc.relation.ispartof | Journal of Venomous Animals and Toxins Including Tropical Diseases | |
dc.relation.ispartofjcr | 1.782 | |
dc.relation.ispartofsjr | 0,573 | |
dc.rights.accessRights | Acesso aberto | |
dc.source | Web of Science | |
dc.subject | differential diagnosis | en |
dc.subject | copper toxicosis | en |
dc.subject | ovines | en |
dc.subject | crotalic venom | en |
dc.subject | hyperimmunization | en |
dc.title | Young ovine death during hyperimmunization: crotalic envenomation or copper toxicosis? | en |
dc.type | Artigo | |
dcterms.license | http://www.scielo.br/revistas/jvatitd/iaboutj.htm | |
dcterms.rightsHolder | Cevap-unesp | |
dspace.entity.type | Publication | |
unesp.author.lattes | 6840524602748457[6] | |
unesp.author.orcid | 0000-0002-9855-5594[6] | |
unesp.campus | Universidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatu | pt |
unesp.department | Doenças Tropicais e Diagnósticos por Imagem - FMB | pt |
Arquivos
Pacote original
1 - 1 de 1
Carregando...
- Nome:
- S1678-91992008000400015-en.pdf
- Tamanho:
- 707.55 KB
- Formato:
- Adobe Portable Document Format
- Descrição:
Licença do pacote
1 - 2 de 2
Carregando...
- Nome:
- license.txt
- Tamanho:
- 1.71 KB
- Formato:
- Item-specific license agreed upon to submission
- Descrição:
Carregando...
- Nome:
- license.txt
- Tamanho:
- 1.71 KB
- Formato:
- Item-specific license agreed upon to submission
- Descrição: