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Young ovine death during hyperimmunization: crotalic envenomation or copper toxicosis?

dc.contributor.authorFerreira Júnior, Rui Seabra [UNESP]
dc.contributor.authorNascimento, N.
dc.contributor.authorCouto, R. [UNESP]
dc.contributor.authorAlves, J. B.
dc.contributor.authorMeira, D. A. [UNESP]
dc.contributor.authorBarraviera, Benedito [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionInstituto de Pesquisas Energéticas e Nucleares (IPEN)
dc.date.accessioned2014-05-20T13:34:31Z
dc.date.available2014-05-20T13:34:31Z
dc.date.issued2008-01-01
dc.description.abstractThe unfavorable evolution of a young ovine during hyperimmunization process with Crotalus durissus terrificus venom was investigated in order to differentiate its origin between ophidic envenomation and copper toxicosis. Clinical, laboratory, necroscopic and histological exams as well as evaluation and measurement of heavy metals (copper) in the kidneys and in the liver were carried out. Blood counts revealed anemia and serological tests showed high levels of blood urea nitrogen, creatinine, aspartate aminotransferase, creatine phosphokinase, total bilirubin and indirect bilirubin; which indicates liver, kidney and skeletal muscle damages. At necropsy, the animal presented hepatopathy and nephropathy. Histological examination revealed renal and hepatic features that may imply copper intoxication. Copper levels were 237.8 mu g/g in the liver and 51.2 mu g/g in the kidneys. Although the amount of metal found in both organs was below the level that can cause death, according to the literature, anatomopathological signs were suggestive of copper intoxication. Therefore, the hypothesis of metal toxicosis during the hyperimmunization process became more consistent than the crotalic envenomation one.en
dc.description.affiliationSão Paulo State Univ, CEVAP, UNESP, Ctr Study Venoms & Venomous Anim, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationSão Paulo State Univ, UNESP, Botucatu Med Sch, Dept Trop Dis, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationIPEN CNEN SP, Inst Nucl Energy Res, São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ, UNESP, Clin Lab Vet, Vet Med & Anim Husb Sch, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, CEVAP, UNESP, Ctr Study Venoms & Venomous Anim, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Botucatu Med Sch, Dept Trop Dis, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Clin Lab Vet, Vet Med & Anim Husb Sch, BR-18618000 Botucatu, SP, Brazil
dc.format.extent738-749
dc.identifierhttp://dx.doi.org/10.1590/S1678-91992008000400015
dc.identifier.citationJournal of Venomous Animals and Toxins Including Tropical Diseases. Botucatu: Cevap-unesp, v. 14, n. 4, p. 738-749, 2008.
dc.identifier.fileS1678-91992008000400015-en.pdf
dc.identifier.issn1678-9199
dc.identifier.scieloS1678-91992008000400015
dc.identifier.urihttp://hdl.handle.net/11449/11843
dc.identifier.wosWOS:000267352500015
dc.language.isoeng
dc.publisherUniversidade Estadual Paulista (Unesp), Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP)
dc.relation.ispartofJournal of Venomous Animals and Toxins Including Tropical Diseases
dc.relation.ispartofjcr1.782
dc.relation.ispartofsjr0,573
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectdifferential diagnosisen
dc.subjectcopper toxicosisen
dc.subjectovinesen
dc.subjectcrotalic venomen
dc.subjecthyperimmunizationen
dc.titleYoung ovine death during hyperimmunization: crotalic envenomation or copper toxicosis?en
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/jvatitd/iaboutj.htm
dcterms.rightsHolderCevap-unesp
dspace.entity.typePublication
unesp.author.lattes6840524602748457[6]
unesp.author.orcid0000-0002-9855-5594[6]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
unesp.departmentDoenças Tropicais e Diagnósticos por Imagem - FMBpt

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