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Effects of Brazilian green propolis extract on planktonic cells and biofilms of multidrug-resistant strains of Klebsiella pneumoniae and Pseudomonas aeruginosa

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dc.contributor.authorSantos, Pâmela Beatriz do Rosário Estevam dos [UNESP]
dc.contributor.authorÁvila, Damara da Silva [UNESP]
dc.contributor.authorRamos, Lucas de Paula [UNESP]
dc.contributor.authorYu, Amanda Romagnoli [UNESP]
dc.contributor.authorSantos, Carlos Eduardo da Rocha [UNESP]
dc.contributor.authorBerretta, Andresa Aparecida
dc.contributor.authorCamargo, Samira Esteves Afonso
dc.contributor.authorOliveira, Jonatas Rafael de
dc.contributor.authorOliveira, Luciane Dias de [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Paulista (UNIP)
dc.contributor.institutionPoliclin Institute for Teaching and Research
dc.contributor.institutionApis Flora Indl. Coml. Ltda
dc.contributor.institutionCollege of Dentistry
dc.contributor.institutionAnhembi Morumbi University
dc.date.accessioned2021-06-25T11:04:13Z
dc.date.available2021-06-25T11:04:13Z
dc.date.issued2020-08-08
dc.description.abstractPropolis could represent an alternative therapeutic agent for targeting multidrug-resistant bacteria due to its antimicrobial potential. The effect of Brazilian green propolis (BGP) aqueous extract (AqExt) was evaluated on eight multidrug-resistant clinical strains of Klebsiella pneumoniae and Pseudomonas aeruginosa, as well as on one reference strain for each bacterial species. The minimum bactericidal concentration (MBC) was determined and optimal concentrations were further evaluated in comparison with 0.12% chlorhexidine. The natural extract was chemically characterized by HPLC-DAD analysis. The MBC values ranged between 3.12 and 27.5 mg ml−1. Analysis of bacterial metabolic activity after treatment for 5 min with BGP-AqExt revealed a strong antimicrobial potential, similar to chlorhexidine. The extract comprised several active compounds including quercetin, gallic acid, caffeic and p-coumaric acid, drupani, galangin, and artepillin C. Altogether, the findings suggest that BGP-AqExt is fast and effective against multidrug-resistant strains of K. pneumoniae and P. aeruginosa in planktonic cultures and biofilms.en
dc.description.affiliationDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (UNESP)
dc.description.affiliationHealth Sciences Institute Universidade Paulista (UNIP)
dc.description.affiliationPoliclin Institute for Teaching and Research
dc.description.affiliationResearch and Development Laboratory Apis Flora Indl. Coml. Ltda
dc.description.affiliationDepartment of Restorative Dental Sciences University of Florida College of Dentistry
dc.description.affiliationSchool of Medicine Anhembi Morumbi University
dc.description.affiliationUnespDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (UNESP)
dc.format.extent834-845
dc.identifierhttp://dx.doi.org/10.1080/08927014.2020.1823972
dc.identifier.citationBiofouling, v. 36, n. 7, p. 834-845, 2020.
dc.identifier.doi10.1080/08927014.2020.1823972
dc.identifier.issn1029-2454
dc.identifier.issn0892-7014
dc.identifier.scopus2-s2.0-85091166894
dc.identifier.urihttp://hdl.handle.net/11449/207974
dc.language.isoeng
dc.relation.ispartofBiofouling
dc.sourceScopus
dc.subjectBiofilm
dc.subjectBrazilian green propolis
dc.subjectKlebsiella pneumoniae
dc.subjectmultidrug-resistant bacteria
dc.subjectPseudomonas aeruginosa
dc.titleEffects of Brazilian green propolis extract on planktonic cells and biofilms of multidrug-resistant strains of Klebsiella pneumoniae and Pseudomonas aeruginosaen
dc.typeArtigo
dspace.entity.typePublication
unesp.author.orcid0000-0002-2682-2796[3]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Ciência e Tecnologia, São José dos Campospt
unesp.departmentBiociências e Diagnóstico Bucal - ICTpt

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São José dos Campos - ICT - Instituto de Ciência e Tecnologia