Amphibian secretions for drug discovery studies: A search for new antiparasitic and antifungal compounds
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Elsevier
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Resumo
The antiparasitic and antifungal activities of nine amphibian skin secretions were studied in different in vitro models. Seven secretions presented a considerable antiprotozoan activity and one showed promising results against Candida sp. These results can be the basis for the development of new drugs, especially for neglected parasitic diseases. © 2007 Bentham Science Publishers Ltd.
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Amphibians , Antimicrobial , Leishmania , Peptides , Secretions , Trypanosoma , amino acid oxidase , amphibian protein , antifungal agent , antiparasitic agent , benznidazole , meglumine antimonate , pentamidine , pyrimethamine , Amphibia , animal cell , animal experiment , animal model , animal tissue , Candida , controlled study , dose response , drug design , drug effect , drug research , enzyme activity , growth inhibition , mouse , nonhuman , priority journal , skin secretion
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Inglês
Citação
Letters in Drug Design and Discovery, v. 4, n. 1, p. 67-73, 2007.
