Publicação: Amphibian secretions for drug discovery studies: A search for new antiparasitic and antifungal compounds
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The antiparasitic and antifungal activities of nine amphibian skin secretions were studied in different in vitro models. Seven secretions presented a considerable antiprotozoan activity and one showed promising results against Candida sp. These results can be the basis for the development of new drugs, especially for neglected parasitic diseases. © 2007 Bentham Science Publishers Ltd.
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Amphibians, Antimicrobial, Leishmania, Peptides, Secretions, Trypanosoma, amino acid oxidase, amphibian protein, antifungal agent, antiparasitic agent, benznidazole, meglumine antimonate, pentamidine, pyrimethamine, Amphibia, animal cell, animal experiment, animal model, animal tissue, Candida, controlled study, dose response, drug design, drug effect, drug research, enzyme activity, growth inhibition, mouse, nonhuman, priority journal, skin secretion
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Inglês
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Letters in Drug Design and Discovery, v. 4, n. 1, p. 67-73, 2007.
