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Amphibian secretions for drug discovery studies: A search for new antiparasitic and antifungal compounds

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dc.contributor.authorTempone, André Gustavo
dc.contributor.authorMelhem, Márcia de Souza Carvalho
dc.contributor.authorPrado, Frederico Oliveira
dc.contributor.authorMotoie, Gabriela
dc.contributor.authorHiramoto, Roberto Mitsuyoshi
dc.contributor.authorAntoniazzi, Marta Maria
dc.contributor.authorHaddad, Celio Fernando Baptista [UNESP]
dc.contributor.authorJared, Carlos
dc.contributor.institutionInstituto Adolfo Lutz (IAL)
dc.contributor.institutionInstituto Butantan
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:22:24Z
dc.date.available2014-05-27T11:22:24Z
dc.date.issued2007-01-10
dc.description.abstractThe antiparasitic and antifungal activities of nine amphibian skin secretions were studied in different in vitro models. Seven secretions presented a considerable antiprotozoan activity and one showed promising results against Candida sp. These results can be the basis for the development of new drugs, especially for neglected parasitic diseases. © 2007 Bentham Science Publishers Ltd.en
dc.description.affiliationLab. Toxinologia Aplicada Departamento de Parasitologia Instituto Adolfo Lutz, Av. Dr. Arnaldo 355, 8 andar, CEP 01246-000 São Paulo
dc.description.affiliationLab. Biologia Celular Instituto Butantan, Av. Vital Brazil, 1500, CEP 05503-900 - São Paulo
dc.description.affiliationDepartamento de Zoologia Instituto de Biociências UNESP, Av. 24 A, 1515, CEP 13.506-900 - Rio Claro, SP
dc.description.affiliationUnespDepartamento de Zoologia Instituto de Biociências UNESP, Av. 24 A, 1515, CEP 13.506-900 - Rio Claro, SP
dc.format.extent67-73
dc.identifierhttp://dx.doi.org/10.2174/157018007778992856
dc.identifier.citationLetters in Drug Design and Discovery, v. 4, n. 1, p. 67-73, 2007.
dc.identifier.doi10.2174/157018007778992856
dc.identifier.issn1570-1808
dc.identifier.lattes0458077399058762
dc.identifier.scopus2-s2.0-33845967153
dc.identifier.urihttp://hdl.handle.net/11449/69512
dc.identifier.wosWOS:000242910300012
dc.language.isoeng
dc.relation.ispartofLetters in Drug Design and Discovery
dc.relation.ispartofjcr0.924
dc.relation.ispartofsjr0,247
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAmphibians
dc.subjectAntimicrobial
dc.subjectLeishmania
dc.subjectPeptides
dc.subjectSecretions
dc.subjectTrypanosoma
dc.subjectamino acid oxidase
dc.subjectamphibian protein
dc.subjectantifungal agent
dc.subjectantiparasitic agent
dc.subjectbenznidazole
dc.subjectmeglumine antimonate
dc.subjectpentamidine
dc.subjectpyrimethamine
dc.subjectAmphibia
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectCandida
dc.subjectcontrolled study
dc.subjectdose response
dc.subjectdrug design
dc.subjectdrug effect
dc.subjectdrug research
dc.subjectenzyme activity
dc.subjectgrowth inhibition
dc.subjectmouse
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectskin secretion
dc.titleAmphibian secretions for drug discovery studies: A search for new antiparasitic and antifungal compoundsen
dc.typeArtigo
dcterms.licensehttp://www.benthamscience.com/permission.php
dspace.entity.typePublication
unesp.author.lattes0458077399058762[7]
unesp.author.orcid0000-0003-2559-7344[1]
unesp.author.orcid0000-0002-9117-6276[8]
unesp.author.orcid0000-0002-9900-1470[1]
unesp.author.orcid0000-0002-1335-8808[2]
unesp.author.orcid0000-0002-7044-5764[7]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Rio Claropt
unesp.departmentZoologia - IBpt

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Rio Claro - IB - Instituto de Biociências