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Stress-induced cross-sensitization to amphetamine is related to changes in the dopaminergic system

dc.contributor.authorCruz, Fabio C. [UNESP]
dc.contributor.authorMarin, Marcelo Tadeu [UNESP]
dc.contributor.authorLeao, Rodrigo Molini [UNESP]
dc.contributor.authorPlaneta, Cleopatra da Silva [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.date.accessioned2014-05-20T13:25:34Z
dc.date.available2014-05-20T13:25:34Z
dc.date.issued2012-04-01
dc.description.abstractRepeated stress engenders behavioral sensitization. The mesolimbic dopamine system is critically involved in drug-induced behavioral sensitization. In the present study we examined the differences between adolescent and adult rats in stress-induced behavioral sensitization to amphetamine and changes in dopamine (DA) and its metabolite levels in the mesolimbic system. Adolescent or adult rats were restrained for 2 h, once a day, for 7 days. Three days after the last exposure to stress, the animals were challenged with saline or amphetamine (1.0 mg/kg i.p.) and amphetamine-induced locomotion was recorded for 40 min. Immediately after the behavioral tests, rats were decapitated and the nucleus accumbens (NAcc), ventral tegmental area (VTA) and amygdala (AM) were removed to measure tissue levels of da and its metabolites by HPLC. Exposure to repeated restraint stress promoted behavioral sensitization to amphetamine in both adult and adolescent rats. In adult rats, amphetamine administration increased da levels in both the stress and control groups in the NAcc and VTA. In adolescent rats, amphetamine increased da levels in the NAcc in rats exposed to stress. Furthermore, in the AM of adolescent rats in the control group, amphetamine increased the da levels; however, amphetamine reduced this neurotransmitter in the rats that were exposed to stress. No alteration was observed in the dopamine metabolite levels. Therefore, stress promoted behavioral sensitization to amphetamine and this may be related to changes in da levels in the mesolimbic system. These changes appear to be dependent on ontogeny.en
dc.description.affiliationSão Paulo State Univ UNESP, Pharmacol Lab, Sch Pharmaceut Sci, BR-14801902 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Carlos (UFSCar), Interinst Grad Program Physiol Sci, BR-13560 São Carlos, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Pharmacol Lab, Sch Pharmaceut Sci, BR-14801902 São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 07/08087-7
dc.format.extent415-424
dc.identifierhttp://dx.doi.org/10.1007/s00702-011-0720-8
dc.identifier.citationJournal of Neural Transmission. Wien: Springer Wien, v. 119, n. 4, p. 415-424, 2012.
dc.identifier.doi10.1007/s00702-011-0720-8
dc.identifier.issn0300-9564
dc.identifier.lattes2514762545280942
dc.identifier.lattes7920438802539727
dc.identifier.orcid0000-0002-1378-6327
dc.identifier.urihttp://hdl.handle.net/11449/8115
dc.identifier.wosWOS:000302423900002
dc.language.isoeng
dc.publisherSpringer Wien
dc.relation.ispartofJournal of Neural Transmission
dc.relation.ispartofjcr2.776
dc.relation.ispartofsjr1,232
dc.rights.accessRightsAcesso restritopt
dc.sourceWeb of Science
dc.subjectAmphetamineen
dc.subjectLocomotor activityen
dc.subjectDopamineen
dc.subjectStressen
dc.titleStress-induced cross-sensitization to amphetamine is related to changes in the dopaminergic systemen
dc.typeArtigopt
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer Wien
dspace.entity.typePublication
relation.isOrgUnitOfPublication95697b0b-8977-4af6-88d5-c29c80b5ee92
relation.isOrgUnitOfPublication.latestForDiscovery95697b0b-8977-4af6-88d5-c29c80b5ee92
unesp.author.lattes7920438802539727
unesp.author.lattes2514762545280942[4]
unesp.author.orcid0000-0002-1378-6327[4]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentPrincípios Ativos Naturais e Toxicologia - FCFpt

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