Publicação:
Efeito das toxinas urêmicas guanidina e ácido guanidinoácetico sobre o metabolismo oxidativo e apoptose em neutrófilos de cães

dc.contributor.advisorCiarlini, Paulo Cesar [UNESP]
dc.contributor.authorPereira, Priscila Preve [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-10-06T13:03:21Z
dc.date.available2015-10-06T13:03:21Z
dc.date.issued2014-01-17
dc.description.abstractIt has been recently reported that in canine chronic renal failure (CRF) there occurs oxidative stress, and that neutrophil dysfunction is associated with the increase of apoptosis. Among the many uremic toxins found in higher concentrations due to CRF, there is evidence - in humans - that guanidines inhibit the oxidative metabolism of neutrophils, affecting their bactericidal function. In this study, a systematic review of the relationship between guanidine compounds and neutrophils in dogs was undertaken. It was found that the literature on this subject is scarce and conflicting, which prompted this investigation of the relationship between the plasmatic concentration of guanidine, the production of superoxide, and the apoptosis of neutrophils in dogs with CRF. Morever, the effect of the isolated compound guanidine acetic acid (GAA) on the production of superoxide and on neutrophil apoptosis in healthy dogs was investigated in vitro. It was possible to verify that the large increase of plasmatic guanidine observed in dogs with CRF is not associated with the altered oxidative metabolism and the apoptosis of the neutrophils. The GAA inhibited the oxidative metabolism of the neutrophils in healthy dogs without affecting the viability of these cellsen
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent50 f.
dc.identifier.aleph000848874
dc.identifier.capes33004021075P8
dc.identifier.citationPEREIRA, Priscila Preve. Efeito das toxinas urêmicas guanidina e ácido guanidinoácetico sobre o metabolismo oxidativo e apoptose em neutrófilos de cães. 2014. 50 f. , 2014.
dc.identifier.filehttp://www.athena.biblioteca.unesp.br/exlibris/bd/cathedra/16-09-2015/000848874.pdf
dc.identifier.lattes3613940018299500
dc.identifier.orcid0000-0003-1480-5208
dc.identifier.urihttp://hdl.handle.net/11449/128114
dc.language.isopor
dc.publisherUniversidade Estadual Paulista (Unesp)
dc.rights.accessRightsAcesso aberto
dc.sourceAleph
dc.subjectUremiapt
dc.subjectApoptosept
dc.subjectLeucócitospt
dc.subjectCãopt
dc.subjectMetabolismopt
dc.subjectGuanidinapt
dc.subjectrespiratory burstpt
dc.titleEfeito das toxinas urêmicas guanidina e ácido guanidinoácetico sobre o metabolismo oxidativo e apoptose em neutrófilos de cãespt
dc.typeDissertação de mestrado
dspace.entity.typePublication
unesp.advisor.lattes3613940018299500
unesp.advisor.orcid0000-0003-1480-5208
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina Veterinária, Araçatubapt
unesp.graduateProgramCiência Animal - FMVApt
unesp.knowledgeAreaFisiopatologia médica e Cirurgicapt
unesp.researchAreaFisiopatologia médica e Cirurgica de pequenos animaispt

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