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Neuromuscular effects of venoms and crotoxin-like proteins from Crotalus durissus ruruima and Crotalus durissus cumanensis

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dc.contributor.authorGarrido Cavalcante, Walter Luis [UNESP]
dc.contributor.authorPonce-Soto, Luis Alberto
dc.contributor.authorMarangoni, Sergio
dc.contributor.authorGallacci, Marcia [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2015-10-21T21:20:50Z
dc.date.available2015-10-21T21:20:50Z
dc.date.issued2015-03-01
dc.description.abstractA myographic study was performed to compare the neuromuscular effects of venoms and crotoxin-like proteins from Crotalus durissus ruruima and Crotalus durissus cumanensis in mice phrenic-diaphragm preparation. It was concluded that both venoms present neurotoxic activity as a consequence of their crotoxin content. Furthermore, crotoxin from C.d. cumanensis is more potent than that from C.d. ruruima venom. At the concentration range in which both venoms express neurotoxic activity, only C.d. cumanensis venom also manifest a direct myotoxic effect that probably involves the synergic participation of other components than crotoxin. (C) 2015 Elsevier Ltd. All rights reserved.en
dc.description.affiliationSao Paulo State University (UNESP), Bioscience Institute of Botucatu, Botucatu, SP, Brazil
dc.description.affiliationUniversity of Campinas (UNICAMP), Biological Institute, Campinas, SP, Brazil
dc.description.affiliationUnespSao Paulo State University (UNESP), Bioscience Institute of Botucatu, Botucatu, SP, Brazil
dc.format.extent46-49
dc.identifierhttp://www.sciencedirect.com/science/article/pii/S0041010115000094
dc.identifier.citationToxicon. Oxford: Pergamon-elsevier Science Ltd, v. 96, p. 46-49, 2015.
dc.identifier.doi10.1016/j.toxicon.2015.01.006
dc.identifier.issn0041-0101
dc.identifier.lattes9353490382598257
dc.identifier.urihttp://hdl.handle.net/11449/129552
dc.identifier.wosWOS:000350922700005
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofToxicon
dc.relation.ispartofjcr2.352
dc.relation.ispartofsjr0,692
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectSnake venomen
dc.subjectNeurotoxinen
dc.subjectNeuromuscular transmissionen
dc.subjectCrotalus subspeciesen
dc.titleNeuromuscular effects of venoms and crotoxin-like proteins from Crotalus durissus ruruima and Crotalus durissus cumanensisen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
unesp.author.lattes9353490382598257
unesp.author.orcid0000-0002-2354-636X[1]
unesp.author.orcid0000-0001-5976-2913[2]
unesp.author.orcid0000-0001-6149-4030[4]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.departmentFarmacologia - IBBpt

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Botucatu - IBB - Instituto de Biociências