Publicação: Comparison of the gastroprotective effect of a diterpene lactone isolated from Croton cajucara with its synthetic derivatives
dc.contributor.author | Melo, P. S. | |
dc.contributor.author | Duran, N. | |
dc.contributor.author | Hiruma-Lima, C. A. | |
dc.contributor.author | Souza-Brito, ARM | |
dc.contributor.author | Haun, M. | |
dc.contributor.institution | Universidade Estadual de Campinas (UNICAMP) | |
dc.contributor.institution | Univ Mogi Cruzes | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2014-05-20T13:49:46Z | |
dc.date.available | 2014-05-20T13:49:46Z | |
dc.date.issued | 2003-08-01 | |
dc.description.abstract | The effect of three new derivatives from dehydrocrotonin (DHC-compound I) on gastric damage indifferent animal models including gastric ulceration induced by a necrotic agent and hypothermic restrained-stress was studied: compound 11 (produced by reducing the cyclohexenone moiety of DHC with NaBH4): compound III (produced by reducing the carbonyls with LiAlH4); and compound IV (produced by transforming the lactone moiety into an amide). Their structures were confirmed on the basis of chemical and physicochemical evidence. When previously administered (p.o.) at a dose of 100 mg/kg, compound II significantly (P < 0.01) reduced gastric injury induced by HCl/ethanol (78%) and indomethacin (88%) better than did reference compound 1 (48 and 43%, respectively). But the anti-ulcerogenic activity of compound II was completely abolished by the stress-induced ulcer. Reduction of carbonyls with LiAlH4 (compound 111) caused decreased activity, markedly when no protective effect in any of the models was applied (P > 0.05). However, compound IV, in which the lactone moiety was changed into an amide. when administered at the same dose (100 mg/kg, p.o.), was more effective. The presence of a lactone moiety or Michael acceptor is probably essential for the anti-ulcerogenic effect of these compounds. (C) 2003 Elsevier B.V. Ireland Ltd. All rights reserved. | en |
dc.description.affiliation | Univ Estadual Campinas, Inst Biol, Dept Bioquim, BR-13081970 Campinas, SP, Brazil | |
dc.description.affiliation | Univ Estadual Campinas, Inst Quim, Lab Quim Biol, BR-13081970 Campinas, SP, Brazil | |
dc.description.affiliation | Univ Mogi Cruzes, BR-08790911 Mogi Das Cruzes, SP, Brazil | |
dc.description.affiliation | Univ Estadual Paulista, Inst Biociencias, Dept Fisiol, BR-18618000 Botucatu, SP, Brazil | |
dc.description.affiliation | Univ Estadual Campinas, Inst Biol, Dept Fisiol & Biofis, BR-13084970 Campinas, SP, Brazil | |
dc.description.affiliationUnesp | Univ Estadual Paulista, Inst Biociencias, Dept Fisiol, BR-18618000 Botucatu, SP, Brazil | |
dc.format.extent | 169-174 | |
dc.identifier | http://dx.doi.org/10.1016/S0378-8741(03)00139-9 | |
dc.identifier.citation | Journal of Ethnopharmacology. Clare: Elsevier Sci Ireland Ltd, v. 87, n. 2-3, p. 169-174, 2003. | |
dc.identifier.doi | 10.1016/S0378-8741(03)00139-9 | |
dc.identifier.issn | 0378-8741 | |
dc.identifier.lattes | 3814504901386844 | |
dc.identifier.orcid | 0000-0002-8645-3777 | |
dc.identifier.uri | http://hdl.handle.net/11449/17750 | |
dc.identifier.wos | WOS:000184438300006 | |
dc.language.iso | eng | |
dc.publisher | Elsevier B.V. | |
dc.relation.ispartof | Journal of Ethnopharmacology | |
dc.relation.ispartofjcr | 3.115 | |
dc.relation.ispartofsjr | 1,150 | |
dc.rights.accessRights | Acesso restrito | |
dc.source | Web of Science | |
dc.subject | gastroprotective activity | pt |
dc.subject | DHC | pt |
dc.subject | Croton cajucara | pt |
dc.title | Comparison of the gastroprotective effect of a diterpene lactone isolated from Croton cajucara with its synthetic derivatives | en |
dc.type | Artigo | |
dcterms.license | http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy | |
dcterms.rightsHolder | Elsevier B.V. | |
dspace.entity.type | Publication | |
unesp.author.lattes | 3814504901386844[3] | |
unesp.author.orcid | 0000-0002-8645-3777[3] | |
unesp.campus | Universidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatu | pt |
unesp.department | Fisiologia - IBB | pt |
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