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Immunohistochemical evaluation of prostaglandin E2 and vascular endothelial growth factor in canine cutaneous mast cell tumours

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dc.contributor.authorAmorim, Renée Laufer [UNESP]
dc.contributor.authorPinczowski, P. [UNESP]
dc.contributor.authorNeto, R. T. [UNESP]
dc.contributor.authorRahal, Sheila Canevese [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:32:07Z
dc.date.available2014-05-20T15:32:07Z
dc.date.issued2010-03-01
dc.description.abstractVascular endothelial growth factor (VEGF) and prostaglandin E2 (PGE-2) appear to play a critical role in tumour neovascularization. In this study, we have investigated the expression of VEGF and PGE-2 in 53 canine cutaneous mast cell tumours (MCTs). Immunohistochemistry of tissue sections revealed that VEGF and PGE-2 were expressed in all mast cell tumours studied. When the expression patterns of VEGF and PGE-2 were compared with tumour grade according to Patnaik criteria, the only significant correlation observed was between PGE-2 staining intensity and tumour pathological grade, with grade II and III tumours having higher PGE-2 staining, both in intensity and percentage of cells stained, than grade I tumours (P < 0.05).en
dc.description.affiliationUniv Estadual Paulista, Sch Vet Med & Anim Sci, Dept Clin Vet Med, BR-18618000 São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Sch Vet Med & Anim Sci, Dept Vet Surg & Anesthesiol, BR-18618000 São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Sch Vet Med & Anim Sci, Dept Clin Vet Med, BR-18618000 São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Sch Vet Med & Anim Sci, Dept Vet Surg & Anesthesiol, BR-18618000 São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent23-27
dc.identifierhttp://dx.doi.org/10.1111/j.1476-5829.2009.00202.x
dc.identifier.citationVeterinary and Comparative Oncology. Malden: Wiley-blackwell Publishing, Inc, v. 8, n. 1, p. 23-27, 2010.
dc.identifier.doi10.1111/j.1476-5829.2009.00202.x
dc.identifier.issn1476-5810
dc.identifier.lattes9795829022108105
dc.identifier.lattes1497433265390194
dc.identifier.orcid0000-0002-9211-4093
dc.identifier.urihttp://hdl.handle.net/11449/41111
dc.identifier.wosWOS:000273912000003
dc.language.isoeng
dc.publisherWiley-Blackwell Publishing, Inc
dc.relation.ispartofVeterinary and Comparative Oncology
dc.relation.ispartofjcr2.270
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectangiogenesisen
dc.subjectcanineen
dc.subjectmast cell tumouren
dc.subjectPGE-2en
dc.subjectVEGFen
dc.titleImmunohistochemical evaluation of prostaglandin E2 and vascular endothelial growth factor in canine cutaneous mast cell tumoursen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-blackwell Publishing, Inc
dspace.entity.typePublication
unesp.author.lattes9795829022108105
unesp.author.lattes1497433265390194
unesp.author.orcid0000-0002-9211-4093[4]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt
unesp.departmentCirurgia e Anestesiologia Veterinária - FMVZpt

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Botucatu - FMVZ - Faculdade de Medicina Veterinária e Zootecnia