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Analysis of metabolic compounds and antitumorigenic effects of Albizia niopoides and Senegalia polyphylla leaves

dc.contributor.authorCagnin Pereira, Thalissa [UNESP]
dc.contributor.authorCardoso, Luana Pereira [UNESP]
dc.contributor.authorda Silva de Paiva, Wesller [UNESP]
dc.contributor.authorSantos de Camargos, Liliane [UNESP]
dc.contributor.authorCristina Rodrigues-Lisoni, Flávia [UNESP]
dc.contributor.authorRedondo Martins, Aline [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2025-04-29T18:50:23Z
dc.date.issued2024-01-01
dc.description.abstractThe objective of this study was to quantify metabolic compounds in leaves of A. niopoides and S. polyphylla and to evaluate the antitumor potential of extracts from both species in cervical tumour cells. The physiological analyses performed were quantification of starch, sucrose, phenolic compounds and proteins. An aqueous extract was prepared and added to the SiHa cell line at concentrations of 10, 100 and 1000 μg/mL at 4h, 24h, 48h and 72h. Cell morphology, proliferation and viability were analysed. The species showed a large amount of starch and phenolic compounds. Treatment with the extract of both species caused morphological changes in SiHa cells and exhibited antiproliferative effects at a concentration of 1000 µg/ml. In cell viability test, only A. niopoides showed a significant reduction. The study presented the effects of the species against a cervical cancer cell line, where A. niopoides has already shown to be a promising plant drug.en
dc.description.affiliationDepartment of Biology and Animal Science Universidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP) Faculdade de Engenharia (Feis), SP
dc.description.affiliationDepartment of Biological Sciences Universidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP) Instituto de Biociências Letras e Ciências Exatas (Ibilce), SP
dc.description.affiliationUnespDepartment of Biology and Animal Science Universidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP) Faculdade de Engenharia (Feis), SP
dc.description.affiliationUnespDepartment of Biological Sciences Universidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP) Instituto de Biociências Letras e Ciências Exatas (Ibilce), SP
dc.identifierhttp://dx.doi.org/10.1080/14786419.2024.2331603
dc.identifier.citationNatural Product Research.
dc.identifier.doi10.1080/14786419.2024.2331603
dc.identifier.issn1478-6427
dc.identifier.issn1478-6419
dc.identifier.scopus2-s2.0-85188699968
dc.identifier.urihttps://hdl.handle.net/11449/300710
dc.language.isoeng
dc.relation.ispartofNatural Product Research
dc.sourceScopus
dc.subjectAntiproliferative effect
dc.subjectcell morphology
dc.subjectfabaceae
dc.subjectphenolic compounds
dc.subjectSiHa
dc.titleAnalysis of metabolic compounds and antitumorigenic effects of Albizia niopoides and Senegalia polyphylla leavesen
dc.typeArtigopt
dspace.entity.typePublication
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Engenharia, Ilha Solteirapt
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Letras e Ciências Exatas, São José do Rio Pretopt

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