Minor furanocoumarins and coumarins in grapefruit peel oil as inhibitors of human cytochrome P450 3A4
| dc.contributor.author | César, Thaïs B. | |
| dc.contributor.author | Manthey, John A. | |
| dc.contributor.author | Myung, Kyung | |
| dc.contributor.institution | Universidade de São Paulo (USP) | |
| dc.contributor.institution | USDA-Agricultural Research Service-South Atlantic Area | |
| dc.date.accessioned | 2022-04-28T18:56:07Z | |
| dc.date.available | 2022-04-28T18:56:07Z | |
| dc.date.issued | 2009-09-25 | |
| dc.description.abstract | A new cyclic acetal (1) of marmin (6′,7′-dihydroxy-7- geranyloxycoumarin), two new cyclic acetals (5, 6) of 6′,7′- dihydroxybergamottin, and the known compounds marmin (2), 7-geranyloxycoumarin (3), bergamottin (4), and 6′,7′-dihydroxybergamottin (7) were isolated from grapefruit peel oil. All compounds were tested for inhibitory activity against intestinal cytochrome P450 3A4, an enzyme involved in the grapefruit/drug interactions in humans. Coumarins (1-3) exhibited negligible inhibitory activity, while the furanocoumarins (4-7) showed potent in vitro inhibitory activity with IC50 values of 2.42, 0.13, 0.27, and 1.58 μM, respectively. | en |
| dc.description.affiliation | School of Pharmaceutical Sciences University of São Paulo State, Araraquara | |
| dc.description.affiliation | U.S. Citrus and Subtropical Products Laboratory USDA-Agricultural Research Service-South Atlantic Area, Winter Haven, FL 33881 | |
| dc.format.extent | 1702-1704 | |
| dc.identifier | http://dx.doi.org/10.1021/np900266m | |
| dc.identifier.citation | Journal of Natural Products, v. 72, n. 9, p. 1702-1704, 2009. | |
| dc.identifier.dimensions | pub.1056237846 | |
| dc.identifier.doi | 10.1021/np900266m | |
| dc.identifier.issn | 0163-3864 | |
| dc.identifier.issn | 1520-6025 | |
| dc.identifier.orcid | 0000-0001-9122-0460 | |
| dc.identifier.orcid | 0000-0001-7878-7075 | |
| dc.identifier.pmid | 19689106 | |
| dc.identifier.scopus | 2-s2.0-70349518908 | |
| dc.identifier.uri | http://hdl.handle.net/11449/219526 | |
| dc.language.iso | eng | |
| dc.publisher | American Chemical Society (ACS) | |
| dc.relation.ispartof | Journal of Natural Products | |
| dc.rights.accessRights | Acesso aberto | pt |
| dc.rights.sourceRights | oa_all | |
| dc.rights.sourceRights | green | |
| dc.source | Scopus | |
| dc.source | Dimensions | |
| dc.title | Minor furanocoumarins and coumarins in grapefruit peel oil as inhibitors of human cytochrome P450 3A4 | en |
| dc.type | Artigo | pt |
| dspace.entity.type | Publication |