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Minor furanocoumarins and coumarins in grapefruit peel oil as inhibitors of human cytochrome P450 3A4

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dc.contributor.authorCésar, Thaïs B.
dc.contributor.authorManthey, John A.
dc.contributor.authorMyung, Kyung
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUSDA-Agricultural Research Service-South Atlantic Area
dc.date.accessioned2022-04-28T18:56:07Z
dc.date.available2022-04-28T18:56:07Z
dc.date.issued2009-09-25
dc.description.abstractA new cyclic acetal (1) of marmin (6′,7′-dihydroxy-7- geranyloxycoumarin), two new cyclic acetals (5, 6) of 6′,7′- dihydroxybergamottin, and the known compounds marmin (2), 7-geranyloxycoumarin (3), bergamottin (4), and 6′,7′-dihydroxybergamottin (7) were isolated from grapefruit peel oil. All compounds were tested for inhibitory activity against intestinal cytochrome P450 3A4, an enzyme involved in the grapefruit/drug interactions in humans. Coumarins (1-3) exhibited negligible inhibitory activity, while the furanocoumarins (4-7) showed potent in vitro inhibitory activity with IC50 values of 2.42, 0.13, 0.27, and 1.58 μM, respectively.en
dc.description.affiliationSchool of Pharmaceutical Sciences University of São Paulo State, Araraquara
dc.description.affiliationU.S. Citrus and Subtropical Products Laboratory USDA-Agricultural Research Service-South Atlantic Area, Winter Haven, FL 33881
dc.format.extent1702-1704
dc.identifierhttp://dx.doi.org/10.1021/np900266m
dc.identifier.citationJournal of Natural Products, v. 72, n. 9, p. 1702-1704, 2009.
dc.identifier.doi10.1021/np900266m
dc.identifier.issn0163-3864
dc.identifier.scopus2-s2.0-70349518908
dc.identifier.urihttp://hdl.handle.net/11449/219526
dc.language.isoeng
dc.relation.ispartofJournal of Natural Products
dc.sourceScopus
dc.titleMinor furanocoumarins and coumarins in grapefruit peel oil as inhibitors of human cytochrome P450 3A4en
dc.typeArtigo
dspace.entity.typePublication

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