The use of a mixture of somatic and culture filtrate antigens in the evaluation of the immune response to Paracoccidioides brasiliensis
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Blackwell Science
Oxford University Press (OUP)
Oxford University Press (OUP)
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Three Paracoccidioides brasiliensis antigens, namely a culture filtrate preparation, a somatic antigen and a mixture of equal parts of the two, were tested by two serological techniques against sera from patients with paracoccidioidomycosis, and in an in vivo delayed hypersensitivity model in mice. The antigen mixture was more sensitive than the two individual antigens for the evaluation of humoral and cellular immune response to P. brasiliensis, both in man and in experimental animals.
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Antigen Vaccine Animal cell Animal tissue Controlled study Culture medium Human Human tissue Immune response Major clinical study Mouse Nonhuman Paracoccidioides brasiliensis Patient Serum Animal Antibodies, Fungal Antigens, Fungal Enzyme-Linked Immunosorbent Assay Human Hypersensitivity, Delayed Immunodiffusion Mice Paracoccidioides Paracoccidioidomycosis Sensitivity and Specificity Animalia Paracoccidioides brasiliensis paracoccidioidomycosis brasiliensis
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Journal of Medical and Veterinary Mycology, v. 29, n. 5, p. 331-334, 1991.
