Syndrome in question: Antisynthetase syndrome (anti-PL-7)
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Antisynthetase syndrome is a rare autoimmune disease characterized by interstitial lung disease and/or inflammatory myositis, with positive antisynthetase antibodies (anti-Jo-1, anti-PL-7, anti-PL-12, ZO, OJ, anti-KE or KS). Other symptoms described include: non-erosive arthritis, fever, Raynaud’s phenomenon, and mechanic’s hands. The first therapeutic option is corticotherapy, followed by other immunosuppressants. The prognosis of the disease is quite limited when compared to other inflammatory myopathies with negative antisynthetase antibodies.
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Amino Acyl-tRNA synthetases, Interstitial lung disease, Myositis
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Anais Brasileiros de Dermatologia, v. 91, n. 5, p. 679-681, 2016.
