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Downmodulation of peripheral MUG-specific immunity by pVAXhspe65 treatment during EAE does not reach the CNS

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dc.contributor.authorGoncalves Zorzella-Pezavento, Sofia Fernanda [UNESP]
dc.contributor.authorChiuso-Minicucci, Fernanda [UNESP]
dc.contributor.authorDonega Franca, Thais Graziela [UNESP]
dc.contributor.authorWatanabe Ishikawa, Larissa Lumi [UNESP]
dc.contributor.authorRosa, Larissa Camargo da [UNESP]
dc.contributor.authorColavite, Priscila Maria [UNESP]
dc.contributor.authorMarques, Camila
dc.contributor.authorValerio Ikoma, Maura Rosane
dc.contributor.authorSilva, Celio Lopes
dc.contributor.authorSartori, Alexandrina [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionFundacao Dr Amaral Carvalho
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-12-03T13:10:54Z
dc.date.available2014-12-03T13:10:54Z
dc.date.issued2014-03-15
dc.description.abstractMost of the therapeutic strategies to control multiple sclerosis are directed to immune modulation and inflammation control. As heat shock proteins are able to induce immunoregulatory T cells, we investigated the therapeutic effect of a genetic vaccine containing the mycobacterial hsp65 gene on experimental autoimmune encephalomyelitis (EAE). Although pVAXhsp65 was immunogenic for mice with EAE and downmodulated specific cytokine induction by MOG, therapy was not able to decrease clinical severity nor to modify immunologic parameters in the CNS. These results indicate that hsp65, administered as a DNA vaccine, was not therapeutic for EAE. (C) 2014 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista UNESP, Dept Microbiol & Immunol, Biosci Inst, BR-18618970 Sao Paulo, Brazil
dc.description.affiliationFundacao Dr Amaral Carvalho, Lab Citometria Fluxo, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Dept Biochem & Immunol, Sao Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Dept Microbiol & Immunol, Biosci Inst, BR-18618970 Sao Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 11/07528-5
dc.format.extent35-42
dc.identifierhttp://dx.doi.org/10.1016/j.jneuroim.2013.12.015
dc.identifier.citationJournal Of Neuroimmunology. Amsterdam: Elsevier Science Bv, v. 268, n. 1-2, p. 35-42, 2014.
dc.identifier.doi10.1016/j.jneuroim.2013.12.015
dc.identifier.issn0165-5728
dc.identifier.lattes4977572416129527
dc.identifier.urihttp://hdl.handle.net/11449/112636
dc.identifier.wosWOS:000333730200004
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Neuroimmunology
dc.relation.ispartofjcr2.655
dc.relation.ispartofsjr1,083
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectExperimental autoimmune encephalomyelitis hsp65en
dc.subjectDNA vaccineen
dc.subjectCD4+CD25+Foxp3+T cellsen
dc.titleDownmodulation of peripheral MUG-specific immunity by pVAXhspe65 treatment during EAE does not reach the CNSen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
unesp.author.lattes4977572416129527[10]
unesp.author.orcid0000-0002-0043-4568[9]
unesp.author.orcid0000-0001-9030-0768[1]
unesp.author.orcid0000-0003-3481-2181[4]
unesp.author.orcid0000-0003-4557-3331[10]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.departmentMicrobiologia e Imunologia - IBBpt

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Botucatu - IBB - Instituto de Biociências