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Chemical and antifungal investigations of six Lippia species (Verbenaceae) from Brazil

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dc.contributor.authorFunari, Cristiano Soleo [UNESP]
dc.contributor.authorGullo, Fernanda Patricia [UNESP]
dc.contributor.authorNapolitano, Assunta
dc.contributor.authorCarneiro, Renato Lajarim
dc.contributor.authorMendes-Giannini, Maria José Soares [UNESP]
dc.contributor.authorFusco-Almeida, Ana Marisa [UNESP]
dc.contributor.authorPiacente, Sonia
dc.contributor.authorPizza, Cosimo
dc.contributor.authorSiqueira Silva, Dulce Helena [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionUniv Salerno
dc.date.accessioned2014-05-20T14:20:39Z
dc.date.available2014-05-20T14:20:39Z
dc.date.issued2012-12-01
dc.description.abstractThe Lippia genus is used in ethnobotany as food, beverages, seasoning and antiseptic remedies, among others. The chemical compositions of fifteen extracts of six Lippia species were investigated comparatively by HPLC-PDA. To avoid data replication of previous works on this genus, Lippia lupulina Cham. root ethanol extract was selected for isolation procedures based on Principal Component Analyses (PCA) of such data. Seven compounds previously unreported in this genus were isolated from this extract (a triterpene, two furanonaphtoquinones, a furanochromone, an isoflavone, a stilbene and an iridoid). The activities of extracts, fractions and pure compounds towards Candida albicans, Candida krusei, Candida parapsilosis and Cryptococcus neoformans were investigated. Two fractions from the extract of Lippia salviaefolia leaves showed marked inhibition of fungal growth, in addition to verbascoside and asebogenin, which showed MICs lower than 15.6 mu g/ml and may be promising leads for the development of new antifungal agents, especially against C. neoformans. (C) 2012 Elsevier Ltd. All rights reserved.en
dc.description.affiliationSão Paulo State Univ, Inst Chem, NuBBE, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationSão Paulo State Univ, Fac Pharmaceut Sci, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUniversidade Federal de São Carlos (UFSCar), Dept Chem, BR-13565905 São Carlos, SP, Brazil
dc.description.affiliationUniv Salerno, Dipartimento Sci Farmaceut, I-84084 Fisciano, SA, Italy
dc.description.affiliationUnespSão Paulo State Univ, Inst Chem, NuBBE, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Fac Pharmaceut Sci, BR-14801902 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 04/07932-7
dc.format.extent2086-2094
dc.identifierhttp://dx.doi.org/10.1016/j.foodchem.2012.06.077
dc.identifier.citationFood Chemistry. Oxford: Elsevier B.V., v. 135, n. 3, p. 2086-2094, 2012.
dc.identifier.doi10.1016/j.foodchem.2012.06.077
dc.identifier.fileWOS000310396700165.pdf
dc.identifier.issn0308-8146
dc.identifier.orcid0000-0002-8059-0826
dc.identifier.urihttp://hdl.handle.net/11449/26194
dc.identifier.wosWOS:000310396700165
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofFood Chemistry
dc.relation.ispartofjcr4.946
dc.relation.ispartofsjr1,793
dc.rights.accessRightsAcesso abertopt
dc.sourceWeb of Science
dc.subjectVerbenaceaeen
dc.subjectLippia sppen
dc.subjectDereplicationen
dc.subjectAntifungalen
dc.subjectCandida spp.en
dc.subjectCryptococcus neoformansen
dc.titleChemical and antifungal investigations of six Lippia species (Verbenaceae) from Brazilen
dc.typeArtigopt
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
relation.isDepartmentOfPublicationa83d26d6-5383-42e4-bb3c-2678a6ddc144
relation.isDepartmentOfPublication.latestForDiscoverya83d26d6-5383-42e4-bb3c-2678a6ddc144
relation.isOrgUnitOfPublication95697b0b-8977-4af6-88d5-c29c80b5ee92
relation.isOrgUnitOfPublication.latestForDiscovery95697b0b-8977-4af6-88d5-c29c80b5ee92
unesp.author.lattes3716273524139678[6]
unesp.author.orcid0000-0002-8059-0826[5]
unesp.author.orcid0000-0002-2115-8988[6]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentAnálises Clínicas - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas