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Arsenic exposure during prepuberty alters prostate maturation in pubescent rats

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dc.contributor.authorAquino, Ariana M. [UNESP]
dc.contributor.authorSalata, Giovanna C. [UNESP]
dc.contributor.authorPinho, Cristiane F. [UNESP]
dc.contributor.authorde Freitas, André T.A.G. [UNESP]
dc.contributor.authorPérico, Larissa L. [UNESP]
dc.contributor.authorde Lion Siervo, Gláucia E.M.
dc.contributor.authorMendes, Leonardo O.
dc.contributor.authorDa Cunha De Medeiros, Paloma
dc.contributor.authorJustulin, Luís A. [UNESP]
dc.contributor.authorFernandes, Glaura S.A.
dc.contributor.authorPerobelli, Juliana E.
dc.contributor.authorScarano, Wellerson R. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv. Oeste Paulista
dc.contributor.institutionUniv. Federal de São Paulo
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)
dc.date.accessioned2019-10-06T15:50:45Z
dc.date.available2019-10-06T15:50:45Z
dc.date.issued2019-10-01
dc.description.abstractArsenic is a widely dispersed chemical compound in the environment and has been associated with the development of some diseases and different types of cancer. Little is known about the action of arsenic compounds on prostate development during prepuberty and puberty. This study evaluated prostate morphophysiology after sodium arsenite exposure during prepubertal period in rats. Male Wistar rats at PND23 were randomly distributed into three experimental groups (n = 10/group). The Ctrl group (filtered drinking water); As1 group (0.01 mg/L of NaAsO2); As2 group (10.0 mg/L of NaAsO2) that received the diluted solution in drinking water from PND23 to PND53. Histological and molecular analyzes showed developmental delay in the As1 group and important morphophysiological alterations in As2 group. The results showed that exposure to NaAsO2 during prepuberty compromised structural and functional maturation of the prostate in pubertal rats at both doses evaluated in this study.en
dc.description.affiliationDepartment of Morphology Sao Paulo State University - UNESP
dc.description.affiliationGraduate Program in Animal Science Univ. Oeste Paulista
dc.description.affiliationInstituto do Mar (IMAR) Univ. Federal de São Paulo
dc.description.affiliationDepartment of General Biology State University of Londrina
dc.description.affiliationUnespDepartment of Morphology Sao Paulo State University - UNESP
dc.format.extent136-144
dc.identifierhttp://dx.doi.org/10.1016/j.reprotox.2019.07.010
dc.identifier.citationReproductive Toxicology, v. 89, p. 136-144.
dc.identifier.doi10.1016/j.reprotox.2019.07.010
dc.identifier.issn1873-1708
dc.identifier.issn0890-6238
dc.identifier.scopus2-s2.0-85069703906
dc.identifier.urihttp://hdl.handle.net/11449/187901
dc.language.isoeng
dc.relation.ispartofReproductive Toxicology
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectArsenic
dc.subjectLate morphogenesis
dc.subjectPostnatal development
dc.subjectProstate
dc.subjectPuberty
dc.titleArsenic exposure during prepuberty alters prostate maturation in pubescent ratsen
dc.typeArtigo
dspace.entity.typePublication

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