The action of aminoguanidine on the liver of trained diabetic rats
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Springer Nature
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Background: This study evaluated the effect of aminoguanidine on liver of diabetic rats subject to physical exercises using histological and histochemical techniques.Methods: The rats used in this study were divided into five groups: sedentary control, sedentary diabetic, trained diabetic, sedentary diabetic and treated with aminoguanidine, trained diabetic and treated with aminoguanidine.Results: The results showed no effect of aminoguanidine on the liver tissue, although there was improvement with exercise training showing cytological, morpho-histological and histochemical alterations in liver cells of animals from groups trained diabetic and/or treated diabetic compared to those individuals in the sedentary control and sedentary diabetic. These changes included: hepatocytes hypertrophy, presence and distribution of polysaccharides in the hepatocytes cytoplasm and, especially, congestion of the liver blood vessels.Conclusion: Our results suggest that aminoguanidine is not hepatotoxic, when used at dosage of 1 g/L for the treatment of diabetes complications, and confirmed that the practice of moderate physical exercise assuaged the damage caused by diabetes without the use of insulin. © 2013 e Nico et al.; licensee BioMed Central Ltd.
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Aminoguanidine , Diabetes type 1 , Liver , Physical exercises , Rats , aminoguanidine , polysaccharide , animal experiment , animal model , animal tissue , cellular distribution , controlled study , cytoplasm , diabetes mellitus , exercise , insulin dependent diabetes mellitus , Kupffer cell , liver , liver blood vessel , liver congestion , liver histology , liver hypertrophy , male , nonhuman , rat
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Inglês
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Journal of Diabetes and Metabolic Disorders, v. 12, n. 1, 2013.
