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Immunogenicity of HLA-DR1 and HLA-A2 peptides derived from Leishmania major Gp63 in golden hamsters

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dc.contributor.authorSilva, Larissa Pinheiro
dc.contributor.authorPaciello, Mauricio Oviedo
dc.contributor.authorAviz Teixeira, Wéllida Patricia
dc.contributor.authorRivas, Açucena Veleh
dc.contributor.authorAgular, Raimundo Wagner Souza
dc.contributor.authorCangussu, Alex Sander Rodrigues
dc.contributor.authorBarbosa, Luiz Carlos Bertucci
dc.contributor.authorMarchetto, Reinaldo [UNESP]
dc.contributor.authorGiunchetti, Rodolfo Cordeiro
dc.contributor.authorViana, Kelvinson Fernandes
dc.contributor.institutionFederal University of Tocantins (UFT)
dc.contributor.institutionFederal University of Latin American Integration (UNILA)
dc.contributor.institutionFederal University of Itajubá
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.date.accessioned2020-12-12T02:18:02Z
dc.date.available2020-12-12T02:18:02Z
dc.date.issued2020-01-01
dc.description.abstractAims: This study aimed to evaluate the toxicity and humoral and cellular immune response of three heterologous vaccines against Leishmania infantum, yet containing synthetic peptides from Leishmania major in the experimental model in hamsters. Methods and Results: Through bioinformatics analyses, two Leishmania major Gp63 peptides were predicted and selected for vaccine formulations. Hamsters were divided into four groups, with each group receiving doses of three vaccine formulations containing HLA-DR1 or HLA-A2 peptides plus MontanideTM or both associated with the adjuvant. The animals received three vaccine doses and were evaluated for toxicity after each dose, in addition to being analysed for the production of antibodies and lymphoproliferation on day 211 after the last vaccine dose. Peptides predicted in association with oily adjuvant induced a humoral response and strong lymphoproliferation to Leishmania infantum antigen-specific stimulation.en
dc.description.affiliationLaboratory of Biomolecules and Vaccines Postgraduate Program in Biotechnology Agrarian Sciences and Technologic Department Federal University of Tocantins (UFT)
dc.description.affiliationPostgraduate Program in Biosciences Interdisciplinary Center for Life Sciences and Nature Federal University of Latin American Integration (UNILA)
dc.description.affiliationBioprocess Engineering and Biotechnology Institute of Natural Resources Federal University of Itajubá
dc.description.affiliationDepartment of Biochemistry and Chemical Technology Institute of Chemistry Universidade Estadual Paulista (UNESP)
dc.description.affiliationLaboratory of Cell-Cell Interactions Morphology Department Institute of Biological Science Federal University of Minas Gerais (UFMG)
dc.description.affiliationUnespDepartment of Biochemistry and Chemical Technology Institute of Chemistry Universidade Estadual Paulista (UNESP)
dc.identifierhttp://dx.doi.org/10.1111/pim.12780
dc.identifier.citationParasite Immunology.
dc.identifier.doi10.1111/pim.12780
dc.identifier.issn1365-3024
dc.identifier.issn0141-9838
dc.identifier.scopus2-s2.0-85089091602
dc.identifier.urihttp://hdl.handle.net/11449/200862
dc.language.isoeng
dc.relation.ispartofParasite Immunology
dc.sourceScopus
dc.subjectadjuvant
dc.subjectbioinformatics
dc.subjectGp63
dc.subjectleishmaniasis
dc.subjectpeptide
dc.subjectvaccine
dc.titleImmunogenicity of HLA-DR1 and HLA-A2 peptides derived from Leishmania major Gp63 in golden hamstersen
dc.typeArtigopt
dspace.entity.typePublication
relation.isOrgUnitOfPublicationbc74a1ce-4c4c-4dad-8378-83962d76c4fd
relation.isOrgUnitOfPublication.latestForDiscoverybc74a1ce-4c4c-4dad-8378-83962d76c4fd
unesp.author.orcid0000-0002-7806-0519[10]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
unesp.departmentBioquímica e Tecnologia - IQpt

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Araraquara - IQAR - Instituto de Química