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Correlation between koilocytes and human papillomavirus detection by PCR in oral and oropharynx squamous cell carcinoma biopsies

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dc.contributor.authorMiyahara, Glauco Issamu [UNESP]
dc.contributor.authorSimonato, Luciana Estevam [UNESP]
dc.contributor.authorMattar, Neivio José [UNESP]
dc.contributor.authorCamilo Jr, Deolino João [UNESP]
dc.contributor.authorBiasoli, Eder Ricardo [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2013-09-30T19:34:45Z
dc.date.accessioned2014-05-20T13:44:34Z
dc.date.available2013-09-30T19:34:45Z
dc.date.available2014-05-20T13:44:34Z
dc.date.issued2011-03-01
dc.description.abstractThe purpose of this study was to compare the histopathological analysis with polymerase chain reaction (PCR) methods to predict the presence of human papillomavirus (HPV) infection in oral squamous cell carcinoma biopsies. Eighty-three paraffin-embedded tissue specimens from patients with oropharynx and mouth floor squamous cell carcinoma were submitted to histopathological analysis under light microscopy, specifically for the determination of the presence of koilocytes. Subsequently, DNA was purified from the same paraffin-embedded specimens and submitted to PCR. Fisher's exact test showed no statistically significant correlation between the two methods. The results suggest that the presence of koilocytes is unreliable for the detection of HPV presence in oral and oropharynx squamous cell carcinoma.en
dc.description.affiliationUniversidade Estadual Paulista Faculdade de Odontologia de Araçatuba Centro de Oncologia Bucal
dc.description.affiliationUnespUniversidade Estadual Paulista Faculdade de Odontologia de Araçatuba Centro de Oncologia Bucal
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipPROINTER (UNESP)
dc.format.extent166-169
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000200008
dc.identifier.citationMemórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 106, n. 2, p. 166-169, 2011.
dc.identifier.dimensionspub.1008717205
dc.identifier.doi10.1590/S0074-02762011000200008
dc.identifier.fileS0074-02762011000200008.pdf
dc.identifier.issn0074-0276
dc.identifier.issn1678-8060
dc.identifier.lattes3846891167083211
dc.identifier.orcid0000-0002-5326-2026
dc.identifier.orcid0000-0002-6413-5479
dc.identifier.orcid0000-0002-5748-9412
dc.identifier.pmid21537675
dc.identifier.scieloS0074-02762011000200008
dc.identifier.urihttp://hdl.handle.net/11449/15625
dc.identifier.wosWOS:000289961100008
dc.language.isoeng
dc.publisherInstituto Oswaldo Cruz, Ministério da Saúde
dc.publisherFapUNIFESP (SciELO)
dc.relation.ispartofMemórias do Instituto Oswaldo Cruz
dc.relation.ispartofjcr2.833
dc.relation.ispartofsjr1,172
dc.rights.accessRightsAcesso abertopt
dc.sourceSciELO
dc.sourceDimensions
dc.subjecthuman papillomavirusen
dc.subjectsquamous cell carcinomaen
dc.subjectmicroscopyen
dc.subjectpolymerase chain reactionen
dc.titleCorrelation between koilocytes and human papillomavirus detection by PCR in oral and oropharynx squamous cell carcinoma biopsiesen
dc.typeArtigopt
dspace.entity.typePublication
unesp.author.lattes3846891167083211[2]
unesp.author.orcid0000-0002-5748-9412[1]
unesp.author.orcid0000-0002-5326-2026[2]

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Araçatuba - COB - Centro de Oncologia Bucal