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Correlations between differences in amino-terminal sequences and different hemolytic activity of sticholysins

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dc.contributor.authorCilli, Eduardo Maffud [UNESP]
dc.contributor.authorPigossi, Fabio T. [UNESP]
dc.contributor.authorCrusca, Edson [UNESP]
dc.contributor.authorRos, Uris
dc.contributor.authorMartinez, Diana
dc.contributor.authorLanio, Maria E.
dc.contributor.authorAlvarez, Carlos
dc.contributor.authorSchreier, Shirley
dc.contributor.institutionUniv La Habana
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T15:20:33Z
dc.date.available2014-05-20T15:20:33Z
dc.date.issued2007-12-15
dc.description.abstractSticholysins I and II (St I and St II) are cytolysins produced by the sea anemone Stichodactyla helianthus. In spite of their 93% sequence homology, St II is more hemolytic against human erythrocytes than St 1. In order to establish the possible causes of this difference, we studied the hemolytic activity of synthetic peptides containing sequences from the N-termini of both proteins. The results demonstrated that the differences in hemolytic activity of the toxins could be ascribed at least partly to differences in their N-termini. (c) 2007 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv La Habana, Fac Biol, Ctr Prot Studies, Havana 10400, Cuba
dc.description.affiliationSão Paulo State Univ, UNESP, Inst Chem, Dept Biochem & Technol Chem, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Inst Chem, Dept Biochem, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Inst Chem, Dept Biochem & Technol Chem, São Paulo, Brazil
dc.format.extent1201-1204
dc.identifierhttp://dx.doi.org/10.1016/j.toxicon.2007.07.013
dc.identifier.citationToxicon. Oxford: Pergamon-Elsevier B.V., v. 50, n. 8, p. 1201-1204, 2007.
dc.identifier.doi10.1016/j.toxicon.2007.07.013
dc.identifier.issn0041-0101
dc.identifier.lattes9424346762460416
dc.identifier.orcid0000-0002-4767-0904
dc.identifier.urihttp://hdl.handle.net/11449/31826
dc.identifier.wosWOS:000251557900017
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofToxicon
dc.relation.ispartofjcr2.352
dc.relation.ispartofsjr0,692
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectsticholysinpt
dc.subjectpeptidespt
dc.subjecthemolytic activitypt
dc.subjectsea anemonept
dc.titleCorrelations between differences in amino-terminal sequences and different hemolytic activity of sticholysinsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
unesp.author.lattes9424346762460416
unesp.author.orcid0000-0002-4767-0904[1]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
unesp.departmentBioquímica e Tecnologia - IQpt

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