Logotipo do repositório
 

Publicação:
Electrochemical Reduction Using Glassy Carbon Electrode in Aqueous Medium of a Potential Anti-Chagas Drug: NFOH

dc.contributor.authorLa-Scalea, M. A.
dc.contributor.authorTrossini, G. H. G.
dc.contributor.authorMenezes, C. M. S.
dc.contributor.authorChung, M. C. [UNESP]
dc.contributor.authorFerreira, E. I.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:25:29Z
dc.date.available2014-05-20T13:25:29Z
dc.date.issued2009-01-01
dc.description.abstractNitrofurazone (NF) presents activity against Chagas' disease, yet it has a high toxicity. Its analog, hydroxymethylnitrofurazone (NFOH), is more potent against Trypanosoma cruzi and much less toxic than the parent drug, NF. The electrochemical reduction of NFOH in an aqueous medium using a glassy carbon electrode (GCE) is presented. By cyclic voltammetry in anacidic medium, one irreversible reduction peak related to hydroxylamine derivative formation was registered, being linearly pH dependent. However, from pH > 7, a reversible reduction peak at a more positive potential appears and corresponds to the formation of a nitro radical anion. The radical-anion kinetic stability was evaluated by Ip(a)/Ip(c) the current ratio of the R-NO(2)/R-NO(2)-redox couple. The nitro radical anion decays with a second-order rate constant (k(2)) of 6.07, 2.06, and 1.44(X 10(3)) L mol(-1) s(-1) corresponding to pH 8.29, 9.29, and 10.2, respectively, with a corresponding half-time life (t(1/2)) of 0.33, 0.97, and 1.4 s for each pH value. By polishing the GCE surface with diamond powder and comparing with the GCE surface polished with alumina, it is shown that the presence of alumina affects the lifetime of the nitro radical anion. (C) 2009 The Electrochemical Society. [DOI: 10.1149/1.3130082] All rights reserved.en
dc.description.affiliationUniv Fed São Paulo, Dept Ciencias Exactas & Terra, Diadema, Brazil
dc.description.affiliationUniv São Paulo, Fac Ciencias Farmaceut, Dept Farm, São Paulo, Brazil
dc.description.affiliationUniv Fed Rio de Janeiro, LaSSBio, Fac Farm, Rio de Janeiro, Brazil
dc.description.affiliationUniv Estadual Julio de Mesquita Filho, Dept Farmacos & Medicamentos, Fac Ciencias Farmaceut, Araraquara, Brazil
dc.description.affiliationUnespUniv Estadual Julio de Mesquita Filho, Dept Farmacos & Medicamentos, Fac Ciencias Farmaceut, Araraquara, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshippostdoctor fellowship
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 01/01192-3
dc.description.sponsorshipIdFAPESP: 03/10763-0
dc.description.sponsorshipIdpostdoctor fellowship: 01/09418-0
dc.description.sponsorshipIdCAPES: 00019-03-8
dc.format.extentF93-F97
dc.identifierhttp://dx.doi.org/10.1149/1.3130082
dc.identifier.citationJournal of The Electrochemical Society. Pennington: Electrochemical Soc Inc, v. 156, n. 7, p. F93-F97, 2009.
dc.identifier.doi10.1149/1.3130082
dc.identifier.fileWOS000267887500046.pdf
dc.identifier.issn0013-4651
dc.identifier.lattes9734333607975413
dc.identifier.orcid0000-0003-4141-0455
dc.identifier.urihttp://hdl.handle.net/11449/8067
dc.identifier.wosWOS:000267887500046
dc.language.isoeng
dc.publisherElectrochemical Soc Inc
dc.relation.ispartofJournal of the Electrochemical Society
dc.relation.ispartofjcr3.662
dc.relation.ispartofsjr1,267
dc.rights.accessRightsAcesso abertopt
dc.sourceWeb of Science
dc.titleElectrochemical Reduction Using Glassy Carbon Electrode in Aqueous Medium of a Potential Anti-Chagas Drug: NFOHen
dc.typeArtigopt
dcterms.licensehttp://www.electrochem.org/dl/support/assets/crtf.pdf
dcterms.rightsHolderElectrochemical Soc Inc
dspace.entity.typePublication
relation.isDepartmentOfPublicatione214da1b-9929-4ae9-b8fd-655e9bfeda4b
relation.isDepartmentOfPublication.latestForDiscoverye214da1b-9929-4ae9-b8fd-655e9bfeda4b
relation.isOrgUnitOfPublication95697b0b-8977-4af6-88d5-c29c80b5ee92
relation.isOrgUnitOfPublication.latestForDiscovery95697b0b-8977-4af6-88d5-c29c80b5ee92
unesp.author.lattes9734333607975413[4]
unesp.author.orcid0000-0003-4141-0455[4]
unesp.author.orcid0000-0003-3634-2531[2]
unesp.author.orcid0000-0003-2087-033X[5]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentFármacos e Medicamentos - FCFpt

Arquivos

Pacote Original

Agora exibindo 1 - 1 de 1
Carregando...
Imagem de Miniatura
Nome:
WOS000267887500046.pdf
Tamanho:
154.79 KB
Formato:
Adobe Portable Document Format

Licença do Pacote

Agora exibindo 1 - 2 de 2
Carregando...
Imagem de Miniatura
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Carregando...
Imagem de Miniatura
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição: