Publicação: Electrochemical Reduction Using Glassy Carbon Electrode in Aqueous Medium of a Potential Anti-Chagas Drug: NFOH
dc.contributor.author | La-Scalea, M. A. | |
dc.contributor.author | Trossini, G. H. G. | |
dc.contributor.author | Menezes, C. M. S. | |
dc.contributor.author | Chung, M. C. [UNESP] | |
dc.contributor.author | Ferreira, E. I. | |
dc.contributor.institution | Universidade Federal de São Paulo (UNIFESP) | |
dc.contributor.institution | Universidade de São Paulo (USP) | |
dc.contributor.institution | Universidade Federal do Rio de Janeiro (UFRJ) | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2014-05-20T13:25:29Z | |
dc.date.available | 2014-05-20T13:25:29Z | |
dc.date.issued | 2009-01-01 | |
dc.description.abstract | Nitrofurazone (NF) presents activity against Chagas' disease, yet it has a high toxicity. Its analog, hydroxymethylnitrofurazone (NFOH), is more potent against Trypanosoma cruzi and much less toxic than the parent drug, NF. The electrochemical reduction of NFOH in an aqueous medium using a glassy carbon electrode (GCE) is presented. By cyclic voltammetry in anacidic medium, one irreversible reduction peak related to hydroxylamine derivative formation was registered, being linearly pH dependent. However, from pH > 7, a reversible reduction peak at a more positive potential appears and corresponds to the formation of a nitro radical anion. The radical-anion kinetic stability was evaluated by Ip(a)/Ip(c) the current ratio of the R-NO(2)/R-NO(2)-redox couple. The nitro radical anion decays with a second-order rate constant (k(2)) of 6.07, 2.06, and 1.44(X 10(3)) L mol(-1) s(-1) corresponding to pH 8.29, 9.29, and 10.2, respectively, with a corresponding half-time life (t(1/2)) of 0.33, 0.97, and 1.4 s for each pH value. By polishing the GCE surface with diamond powder and comparing with the GCE surface polished with alumina, it is shown that the presence of alumina affects the lifetime of the nitro radical anion. (C) 2009 The Electrochemical Society. [DOI: 10.1149/1.3130082] All rights reserved. | en |
dc.description.affiliation | Univ Fed São Paulo, Dept Ciencias Exactas & Terra, Diadema, Brazil | |
dc.description.affiliation | Univ São Paulo, Fac Ciencias Farmaceut, Dept Farm, São Paulo, Brazil | |
dc.description.affiliation | Univ Fed Rio de Janeiro, LaSSBio, Fac Farm, Rio de Janeiro, Brazil | |
dc.description.affiliation | Univ Estadual Julio de Mesquita Filho, Dept Farmacos & Medicamentos, Fac Ciencias Farmaceut, Araraquara, Brazil | |
dc.description.affiliationUnesp | Univ Estadual Julio de Mesquita Filho, Dept Farmacos & Medicamentos, Fac Ciencias Farmaceut, Araraquara, Brazil | |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.description.sponsorship | postdoctor fellowship | |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
dc.description.sponsorshipId | FAPESP: 01/01192-3 | |
dc.description.sponsorshipId | FAPESP: 03/10763-0 | |
dc.description.sponsorshipId | postdoctor fellowship: 01/09418-0 | |
dc.description.sponsorshipId | CAPES: 00019-03-8 | |
dc.format.extent | F93-F97 | |
dc.identifier | http://dx.doi.org/10.1149/1.3130082 | |
dc.identifier.citation | Journal of The Electrochemical Society. Pennington: Electrochemical Soc Inc, v. 156, n. 7, p. F93-F97, 2009. | |
dc.identifier.doi | 10.1149/1.3130082 | |
dc.identifier.file | WOS000267887500046.pdf | |
dc.identifier.issn | 0013-4651 | |
dc.identifier.lattes | 9734333607975413 | |
dc.identifier.orcid | 0000-0003-4141-0455 | |
dc.identifier.uri | http://hdl.handle.net/11449/8067 | |
dc.identifier.wos | WOS:000267887500046 | |
dc.language.iso | eng | |
dc.publisher | Electrochemical Soc Inc | |
dc.relation.ispartof | Journal of the Electrochemical Society | |
dc.relation.ispartofjcr | 3.662 | |
dc.relation.ispartofsjr | 1,267 | |
dc.rights.accessRights | Acesso aberto | pt |
dc.source | Web of Science | |
dc.title | Electrochemical Reduction Using Glassy Carbon Electrode in Aqueous Medium of a Potential Anti-Chagas Drug: NFOH | en |
dc.type | Artigo | pt |
dcterms.license | http://www.electrochem.org/dl/support/assets/crtf.pdf | |
dcterms.rightsHolder | Electrochemical Soc Inc | |
dspace.entity.type | Publication | |
relation.isDepartmentOfPublication | e214da1b-9929-4ae9-b8fd-655e9bfeda4b | |
relation.isDepartmentOfPublication.latestForDiscovery | e214da1b-9929-4ae9-b8fd-655e9bfeda4b | |
relation.isOrgUnitOfPublication | 95697b0b-8977-4af6-88d5-c29c80b5ee92 | |
relation.isOrgUnitOfPublication.latestForDiscovery | 95697b0b-8977-4af6-88d5-c29c80b5ee92 | |
unesp.author.lattes | 9734333607975413[4] | |
unesp.author.orcid | 0000-0003-4141-0455[4] | |
unesp.author.orcid | 0000-0003-3634-2531[2] | |
unesp.author.orcid | 0000-0003-2087-033X[5] | |
unesp.campus | Universidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquara | pt |
unesp.department | Fármacos e Medicamentos - FCF | pt |
Arquivos
Pacote Original
1 - 1 de 1
Carregando...
- Nome:
- WOS000267887500046.pdf
- Tamanho:
- 154.79 KB
- Formato:
- Adobe Portable Document Format
Licença do Pacote
1 - 2 de 2
Carregando...
- Nome:
- license.txt
- Tamanho:
- 1.71 KB
- Formato:
- Item-specific license agreed upon to submission
- Descrição:
Carregando...
- Nome:
- license.txt
- Tamanho:
- 1.71 KB
- Formato:
- Item-specific license agreed upon to submission
- Descrição: