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Motivation and frustration in cardiology trial participation: The patient perspective

dc.contributor.authorMeneguin, Silmara [UNESP]
dc.contributor.authorMachado Cesar, Luiz Antonio
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T13:34:52Z
dc.date.available2014-05-20T13:34:52Z
dc.date.issued2012-01-01
dc.description.abstractOBJECTIVE: The participation of humans in clinical cardiology trials remains essential, but little is known regarding participant perceptions of such studies. We examined the factors that motivated participation in such studies, as well as those that led to participant frustration.METHODS: Patients who had participated in hypertension and coronary arterial disease (phases II, III, and IV) clinical trials were invited to answer a questionnaire. They were divided into two groups: Group I, which included participants in placebo-controlled clinical trials after randomization, and Group II, which included participants in clinical trials in which the tested treatment was compared to another drug after randomization and in which a placebo was used in the washout period.RESULTS: Eighty patients (47 patients in Group I and 33 patients in Group II) with different socio-demographic characteristics were interviewed. Approximately 60% of the patients were motivated to participate in the trial with the expectation of personal benefit. Nine participants (11.2%) expressed the desire to withdraw, which was due to their perception of risk during the testing in the clinical trial (Group I) and to the necessity of repeated returns to the institution (Group II). However, the patients did not withdraw due to fear of termination of hospital treatment.CONCLUSIONS: Although this study had a small patient sample, the possibility of receiving a benefit from the new tested treatment was consistently reported as a motivation to participate in the trials.en
dc.description.affiliationUniv Estadual Paulista, Botucatu Sch Med, Dept Nursing, Botucatu, SP, Brazil
dc.description.affiliationUniv São Paulo INCOR, Dept Cardiopneumol, Inst Coracao, Fac Med,Hosp Clin, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Botucatu Sch Med, Dept Nursing, Botucatu, SP, Brazil
dc.format.extent603-607
dc.identifierhttp://dx.doi.org/10.6061/clinics/2012(06)10
dc.identifier.citationClinics. São Paulo: Hospital Clinicas, Univ São Paulo, v. 67, n. 6, p. 603-607, 2012.
dc.identifier.doi10.6061/clinics/2012(06)10
dc.identifier.fileS1807-59322012000600010.pdf
dc.identifier.issn1807-5932
dc.identifier.lattes5997609813899904
dc.identifier.scieloS1807-59322012000600010
dc.identifier.urihttp://hdl.handle.net/11449/11962
dc.identifier.wosWOS:000305982700010
dc.language.isoeng
dc.publisherUniversidade de São Paulo (USP), Hospital das Clínicas
dc.relation.ispartofClinics
dc.relation.ispartofjcr1.245
dc.relation.ispartofsjr0,536
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectMotivationen
dc.subjectClinical trialsen
dc.subjectFrustrationen
dc.subjectCardiologyen
dc.titleMotivation and frustration in cardiology trial participation: The patient perspectiveen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/clin/paboutj.htm
dcterms.rightsHolderHospital Clinicas, Univ São Paulo
dspace.entity.typePublication
unesp.author.lattes5997609813899904
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
unesp.departmentEnfermagem - FMBpt

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