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Imidazoline receptors of the paraventricular nucleus on the pressor response induced by stimulation of the subfornical organ

dc.contributor.authorSaad, W. A.
dc.contributor.authorCamargo, LAD
dc.contributor.authorSilveira, JEN
dc.contributor.authorSaad, R.
dc.contributor.authorCamargo, GMPD
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUNITAU
dc.date.accessioned2014-05-20T13:45:40Z
dc.date.available2014-05-20T13:45:40Z
dc.date.issued1998-02-01
dc.description.abstractIn the present experiments we investigated a possible involvement of imidazoline receptors of the paraventricular nucleus (PVN) of the hypothalamus on the presser effects of the angiotensin LI (ANG II) injected into the subfornical organ (SFO), in male Holtzman rats (250-300 g) with a cannula implanted into the third ventricle (3rdV), PVN and SFO. At first we tested the participation of alpha(2) and imidazoline agonist and antagonist compounds on the presser effect of ANG II injected into the 3rdV. Based on the results we may conclude that clonidine associated with rilmenidine was able to block the hypertensive response to ANG IT. The ANG II (20 pmol) injected into SFO induced a robust increase in blood pressure (37 +/- 2 mmHg). Isotonic saline (0.15 M) NaCl did not produce any change in blood pressure (5 +/- 2 mmHg). The injection of rilmenidine (30 mu g/kg/l mu L), an imidazoline agonist agent injected into PVN before ANG II injection into SFO, blocked the presser effect of ANG II (5 +/- 2 mmHg). Also, the injection of idazoxan (60 mu g/kg/mu L) before rilmenidine blocked the inhibitory effect of rilmenidine on blood pressure (39 +/- 4 mmHg). The injection of clonidine (20 nmol/mu L) prior to ANG II into the 3rdV produced a decreased in arterial blood pressure (37 +/- 2 mmHg) to (15 +/- 4 mmHg). The injection of yohimbine (80 nmol/mu L) prior to clonidine blocked the effect of clonidine on the effect of ANG II (27 +/- 2 mmHg). The injection of rilmenidine prior to ANG TI also induced a decrease in arterial blood pressure (10 +/- 3 mmHg). The injection of idazoxan prior to rilmenidine also blocked the inhibitory effect of rilmenidine (24 +/- 3 mmHg). In summary, the present study demonstrated that rilmenidine decreases the hypertensive effect of ANG II, with more potency than clonidine, even when injected into 3rdV or PVN. This study established that the PVN interacts with SFO by imidazoline receptors in order to control the arterial blood pressure. (C) Elsevier, Paris.en
dc.description.affiliationUNESP, Paulista State Univ, Sch Dent, Dept Physiol, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliationUNITAU, Dept Dent, Taubate, SP, Brazil
dc.description.affiliationUnespUNESP, Paulista State Univ, Sch Dent, Dept Physiol, BR-14801903 Araraquara, SP, Brazil
dc.format.extent25-30
dc.identifierhttp://dx.doi.org/10.1016/S0928-4257(98)80019-3
dc.identifier.citationJournal of Physiology-paris. Paris Cedex 15: Editions Scientifiques Medicales Elsevier, v. 92, n. 1, p. 25-30, 1998.
dc.identifier.doi10.1016/S0928-4257(98)80019-3
dc.identifier.issn0928-4257
dc.identifier.urihttp://hdl.handle.net/11449/16077
dc.identifier.wosWOS:000073670700004
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Physiology-paris
dc.relation.ispartofsjr1,379
dc.rights.accessRightsAcesso restritopt
dc.sourceWeb of Science
dc.subjectimidazolinept
dc.subjectangiotensin IIpt
dc.subjectsubfornical organpt
dc.subjectparaventricular nucleuspt
dc.titleImidazoline receptors of the paraventricular nucleus on the pressor response induced by stimulation of the subfornical organen
dc.typeArtigopt
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
relation.isDepartmentOfPublicationb3ba3d9c-022e-4521-8805-0bcceea7372e
relation.isDepartmentOfPublication.latestForDiscoveryb3ba3d9c-022e-4521-8805-0bcceea7372e
relation.isOrgUnitOfPublicationca4c0298-cd82-48ee-a9c8-c97704bac2b0
relation.isOrgUnitOfPublication.latestForDiscoveryca4c0298-cd82-48ee-a9c8-c97704bac2b0
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araraquarapt
unesp.departmentFisiologia e Patologia - FOARpt

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