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Calcium homeostasis in trypanosomatids: A review of molecular targets and inhibitors

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dc.contributor.authorCoelho, Natália Caroline Costa [UNESP]
dc.contributor.authorVelásquez, Angela Maria Arenas [UNESP]
dc.contributor.authorde Lima, Jhonatan Santos [UNESP]
dc.contributor.authorRamos, Ana Laura Dias [UNESP]
dc.contributor.authorCilli, Eduardo Maffud [UNESP]
dc.contributor.authorGraminha, Marcia A S [UNESP]
dc.date.accessioned2026-05-11T19:04:58Z
dc.date.issued2025-10-22
dc.description.abstractCalcium ion (Ca²⁺) signaling plays a pivotal role in the survival, differentiation, and virulence of trypanosomatids, including Leishmania spp., Trypanosoma brucei, and Trypanosoma cruzi, making it an attractive therapeutic target. This review integrates current knowledge on Ca²⁺ homeostasis in these parasites, addressing the plasma membrane, endoplasmic reticulum (ER), acidocalcisomes, mitochondria, lysosomes, and other organelles, with particular emphasis on key transporters and signaling pathways. In addition, we summarize genetic and pharmacological strategies used to validate Ca²⁺-related targets and highlight recent advances in both repurposed and novel compounds that disrupt Ca²⁺ homeostasis in trypanosomatids.
dc.description.affiliationSchool of Pharmaceutical Sciences, São Paulo State University (UNESP), 14800-903 Araraquara, SP, Brazil.
dc.description.affiliationSchool of Pharmaceutical Sciences, São Paulo State University (UNESP), 14800-903 Araraquara, SP, Brazil; Latin American Institute of Life and Nature Sciences, Federal University of Latin American Integration (UNILA), Foz do Iguaçu 85870-650, Brazil.
dc.description.affiliationDepartment of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), 14800-060 Araraquara, SP, Brazil.
dc.description.affiliationSchool of Pharmaceutical Sciences, São Paulo State University (UNESP), 14800-903 Araraquara, SP, Brazil. Electronic address: marcia.graminha@unesp.br.
dc.description.affiliationUnespSchool of Pharmaceutical Sciences, São Paulo State University (UNESP), 14800-903 Araraquara, SP, Brazil.
dc.description.affiliationUnespSchool of Pharmaceutical Sciences, São Paulo State University (UNESP), 14800-903 Araraquara, SP, Brazil; Latin American Institute of Life and Nature Sciences, Federal University of Latin American Integration (UNILA), Foz do Iguaçu 85870-650, Brazil.
dc.description.affiliationUnespDepartment of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), 14800-060 Araraquara, SP, Brazil.
dc.description.affiliationUnespSchool of Pharmaceutical Sciences, São Paulo State University (UNESP), 14800-903 Araraquara, SP, Brazil. Electronic address: marcia.graminha@unesp.br.
dc.identifierhttps://app.dimensions.ai/details/publication/pub.1194194381
dc.identifier.dimensionspub.1194194381
dc.identifier.doi10.1016/j.ceca.2025.103086
dc.identifier.issn0143-4160
dc.identifier.issn1532-1991
dc.identifier.orcid0000-0002-5655-5449
dc.identifier.orcid0000-0002-4767-0904
dc.identifier.orcid0000-0001-7280-3775
dc.identifier.pmid41161064
dc.identifier.urihttps://hdl.handle.net/11449/323676
dc.publisherElsevier
dc.relation.ispartofCell Calcium; v. 132; p. 103086
dc.rights.accessRightsAcesso restritopt
dc.rights.sourceRightsclosed
dc.sourceDimensions
dc.titleCalcium homeostasis in trypanosomatids: A review of molecular targets and inhibitors
dc.typeArtigopt
dspace.entity.typePublication
relation.isOrgUnitOfPublication95697b0b-8977-4af6-88d5-c29c80b5ee92
relation.isOrgUnitOfPublicationbc74a1ce-4c4c-4dad-8378-83962d76c4fd
relation.isOrgUnitOfPublication.latestForDiscovery95697b0b-8977-4af6-88d5-c29c80b5ee92
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas
Araraquara - IQAR - Instituto de Química