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Cytotoxic screening of plants from the Brazilian Atlantic Forest has led to the identification of Casearia arborea and Sorocea hilarii as sources of antitumor compounds

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dc.contributor.authorRodrigues, L. A.
dc.contributor.authorAlmeida, A. A.
dc.contributor.authorAgrizii, A. P.
dc.contributor.authorPacheco, N.
dc.contributor.authorCarvalho, B. C.R.
dc.contributor.authorZanatta, A. C. [UNESP]
dc.contributor.authorKohlhoff, M.
dc.contributor.authorTorres, C. M.M.E.
dc.contributor.authorBressan, G. C.
dc.contributor.authorLeite, J. P.V.
dc.contributor.institutionUniversidade Federal de Viçosa (UFV)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionFiocruz
dc.date.accessioned2025-04-29T18:50:45Z
dc.date.issued2024-01-01
dc.description.abstractIn the present study, we have evaluated the cytotoxic activity of 282 extracts from 72 native plant species of the Brazilian Atlantic Forest biome. As a result, Casearia arborea and Sorocea hilarii leaves extracts showed cytotoxic activity against three tumour cell lines tested (B16F10, SW480 and Jurkat). After bioassay-guided fractionation, the bioactive fractions were submitted to the dereplication study via High-performance Liquid Chromatography, connected to High-resolution Mass Spectrometry (HPLC-ESI-QTOF/MS) analysis, combined with a Global Natural Products Social Molecular Networking (GNPS) tool. A combination of bioactivity-guided and dereplication approaches resulted in the putative annotation of 27 clerodane diterpenes and 9 flavonoids as main compounds present in the cytotoxic fractions of C. arborea. Regarding the active fraction of S. hilarii, 10 megastigmans, 17 spirostane steroids derivatives and 2 lignans were putatively identified. In conclusion, Casearia arborea and Sorocea hilarii are potential sources of antitumor compounds.en
dc.description.affiliationDepartamento de Bioquímica e Biologia Molecular Universidade Federal de Viçosa, Minas Gerais
dc.description.affiliationUniversidade Estadual Paulista (Unesp) Instituto de Química, São Paulo
dc.description.affiliationRene Rachou Research Center Fiocruz, Minas Gerais
dc.description.affiliationDepartamento de Engenharia Florestal Universidade Federal de Viçosa, Minas Gerais
dc.description.affiliationUnespUniversidade Estadual Paulista (Unesp) Instituto de Química, São Paulo
dc.format.extent1950-1955
dc.identifierhttp://dx.doi.org/10.1080/14786419.2023.2225689
dc.identifier.citationNatural Product Research, v. 38, n. 11, p. 1950-1955, 2024.
dc.identifier.doi10.1080/14786419.2023.2225689
dc.identifier.issn1478-6427
dc.identifier.issn1478-6419
dc.identifier.scopus2-s2.0-85162979111
dc.identifier.urihttps://hdl.handle.net/11449/300839
dc.language.isoeng
dc.relation.ispartofNatural Product Research
dc.sourceScopus
dc.subjectCasearia arborea
dc.subjectCytotoxic
dc.subjectdereplication
dc.subjectGNPS
dc.subjectSorocea hilarii
dc.titleCytotoxic screening of plants from the Brazilian Atlantic Forest has led to the identification of Casearia arborea and Sorocea hilarii as sources of antitumor compoundsen
dc.typeArtigopt
dspace.entity.typePublication
relation.isOrgUnitOfPublicationbc74a1ce-4c4c-4dad-8378-83962d76c4fd
relation.isOrgUnitOfPublication.latestForDiscoverybc74a1ce-4c4c-4dad-8378-83962d76c4fd
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt

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