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Human herpesvirus type 6 and type 1 infection increases susceptibility to nonmelanoma skin tumors

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dc.contributor.authorLeite, J. L.
dc.contributor.authorStolf, Hamilton Ometto [UNESP]
dc.contributor.authorReis, N. A.
dc.contributor.authorWard, L. S.
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:29:06Z
dc.date.available2014-05-20T15:29:06Z
dc.date.issued2005-06-28
dc.description.abstractIn order to investigate herpesvirus (HHV) role in the susceptibility to skin cancer, we compared HHV6 and HHV1 incidence in DNA samples extracted from 120 lesions and 41 normal skin tissues. HHV6 (31.7%) and HHV1 (23.8%) were detected more frequently in skin cancer than in control individuals (14.6 and 5%, respectively) (P=0.0391 and P=0.00094, respectively). The risk of presenting basal cell carcinomas (BCC) was more than 3 times higher for HHV-6 infected patients (OR=3.182; 95% CI: 1.125-8.997). The risk for HHV-1 infected individuals of presenting BCC and squamous cell carcinomas was increased 8 and 6 times, respectively (OR=8.125; 95% CI: 1.735-38.043 and OR=6.290; 95% CI: 1.283-30.856, respectively). (c) 2004 Elsevier B.V.. All rights reserved.en
dc.description.affiliationState Univ Campinas, Sch Med, Dept Med, Lab Canc Mol Genet, BR-13085045 São Paulo, Brazil
dc.description.affiliationUNESP, Sch Med, Dept Med, São Paulo, Brazil
dc.description.affiliationUnespUNESP, Sch Med, Dept Med, São Paulo, Brazil
dc.format.extent213-219
dc.identifierhttp://dx.doi.org/10.1016/j.canlet.2004.11.010
dc.identifier.citationCancer Letters. Clare: Elsevier B.V., v. 224, n. 2, p. 213-219, 2005.
dc.identifier.doi10.1016/j.canlet.2004.11.010
dc.identifier.issn0304-3835
dc.identifier.lattes1885384405893048
dc.identifier.urihttp://hdl.handle.net/11449/38763
dc.identifier.wosWOS:000229850900005
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofCancer Letters
dc.relation.ispartofjcr6.491
dc.relation.ispartofsjr2,350
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectherpesviruspt
dc.subjectcutaneouspt
dc.subjectcancerpt
dc.subjectinfectionpt
dc.subjectviruspt
dc.subjectsusceptibilitypt
dc.titleHuman herpesvirus type 6 and type 1 infection increases susceptibility to nonmelanoma skin tumorsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
unesp.author.lattes1885384405893048
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
unesp.departmentDermatologia e Radioterapia - FMBpt

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Botucatu - FMB - Faculdade de Medicina