New destruxins from the marine-derived fungus Beauveria felina
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Springer Nature
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Chemical investigation of the cytotoxic and anti-tuberculosis active butanone extract obtained from the growth media of the marine-derived fungus Beauveria felina led to the isolation of two new destruxins, [β-MePro] destruxin E chlorohydrin (1) and pseudodestruxin C (3), along with five known cyclic depsipeptides. The structures of the new destruxin derivatives were established by analysis of spectroscopic data, while the absolute configuration of the common amino acid residues was established by Marfey's analysis. The absolute configuration of the 2(A),4(5)-5-chloro-2,4-dihydroxypentanoic acid residue in 1 could be established by application of a J-based configuration method followed by derivatization with R-MPA-Cl and NMR analysis. © Japan Antibiotics Research Association.
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Beauveria felina Destruxins Fungi Marine microorganisms 2,4 5 chloro 2,4 dihydroxypentanoic acid beta methylprolyldestruxin e chlorohydrin cyclodepsipeptide destruxin destruxin e chlorohydrin isariin b phenylalanyl, n methylvalyldestruxin b pseudodestruxin c roseocardin roseotoxin b unclassified drug valeric acid derivative animal cell antibacterial activity Beauveria cancer cell culture controlled study cytotoxicity derivatization drug isolation fungus high performance liquid chromatography human human cell hydrolysis mouse nonhuman priority journal proton nuclear magnetic resonance spectroscopy stereochemistry Amino Acids Animals Antibiotics, Antineoplastic Antibiotics, Antitubercular Cell Line, Tumor Depsipeptides Fungal Proteins Humans Mice Molecular Structure Mycobacterium tuberculosis Mycotoxins Spectrum Analysis
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Journal of Antibiotics, v. 59, n. 9, p. 553-563, 2006.
