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New destruxins from the marine-derived fungus Beauveria felina

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dc.contributor.authorLira, Simone P.
dc.contributor.authorVita-Marques, Aline M.
dc.contributor.authorSeleghim, Mirna H. R.
dc.contributor.authorBugni, Tim S.
dc.contributor.authorLaBarbera, Daniel V.
dc.contributor.authorSette, Lara D.
dc.contributor.authorSponchiado, Sandra Regina Pombeiro [UNESP]
dc.contributor.authorIreland, Chris M.
dc.contributor.authorBerlinck, Roberto G. S.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversity of Utah
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:21:57Z
dc.date.available2014-05-27T11:21:57Z
dc.date.issued2006-09-01
dc.description.abstractChemical investigation of the cytotoxic and anti-tuberculosis active butanone extract obtained from the growth media of the marine-derived fungus Beauveria felina led to the isolation of two new destruxins, [β-MePro] destruxin E chlorohydrin (1) and pseudodestruxin C (3), along with five known cyclic depsipeptides. The structures of the new destruxin derivatives were established by analysis of spectroscopic data, while the absolute configuration of the common amino acid residues was established by Marfey's analysis. The absolute configuration of the 2(A),4(5)-5-chloro-2,4-dihydroxypentanoic acid residue in 1 could be established by application of a J-based configuration method followed by derivatization with R-MPA-Cl and NMR analysis. © Japan Antibiotics Research Association.en
dc.description.affiliationInstituto de Química de São Carlos Universidade de São Paulo, CP 780, CEP 13560-970, São Carlos, SP
dc.description.affiliationDepartment of Medicinal Chemistry University of Utah, Salt Lake City, UT 84112
dc.description.affiliationDivisão de Recursos Microbianos Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas Universidade Estadual de Campinas, CP 6171, 13083-970, Campinas, SP
dc.description.affiliationDepartamento de Bioquímica e Tecnologia Química Universidade Estadual Paulista, Araraquara, SP
dc.description.affiliationUnespDepartamento de Bioquímica e Tecnologia Química Universidade Estadual Paulista, Araraquara, SP
dc.format.extent553-563
dc.identifierhttp://dx.doi.org/10.1038/ja.2006.76
dc.identifier.citationJournal of Antibiotics, v. 59, n. 9, p. 553-563, 2006.
dc.identifier.doi10.1038/ja.2006.76
dc.identifier.issn0021-8820
dc.identifier.lattes8344823760633809
dc.identifier.orcid0000-0002-3250-8891
dc.identifier.scopus2-s2.0-33751253424
dc.identifier.urihttp://hdl.handle.net/11449/69055
dc.identifier.wosWOS:000241312900004
dc.language.isoeng
dc.relation.ispartofJournal of Antibiotics
dc.relation.ispartofjcr2.033
dc.relation.ispartofsjr0,762
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectBeauveria felina
dc.subjectDestruxins
dc.subjectFungi
dc.subjectMarine microorganisms
dc.subject2,4 5 chloro 2,4 dihydroxypentanoic acid
dc.subjectbeta methylprolyldestruxin e chlorohydrin
dc.subjectcyclodepsipeptide
dc.subjectdestruxin
dc.subjectdestruxin e chlorohydrin
dc.subjectisariin b
dc.subjectphenylalanyl, n methylvalyldestruxin b
dc.subjectpseudodestruxin c
dc.subjectroseocardin
dc.subjectroseotoxin b
dc.subjectunclassified drug
dc.subjectvaleric acid derivative
dc.subjectanimal cell
dc.subjectantibacterial activity
dc.subjectBeauveria
dc.subjectcancer cell culture
dc.subjectcontrolled study
dc.subjectcytotoxicity
dc.subjectderivatization
dc.subjectdrug isolation
dc.subjectfungus
dc.subjecthigh performance liquid chromatography
dc.subjecthuman
dc.subjecthuman cell
dc.subjecthydrolysis
dc.subjectmouse
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectproton nuclear magnetic resonance
dc.subjectspectroscopy
dc.subjectstereochemistry
dc.subjectAmino Acids
dc.subjectAnimals
dc.subjectAntibiotics, Antineoplastic
dc.subjectAntibiotics, Antitubercular
dc.subjectCell Line, Tumor
dc.subjectDepsipeptides
dc.subjectFungal Proteins
dc.subjectHumans
dc.subjectMice
dc.subjectMolecular Structure
dc.subjectMycobacterium tuberculosis
dc.subjectMycotoxins
dc.subjectSpectrum Analysis
dc.titleNew destruxins from the marine-derived fungus Beauveria felinaen
dc.typeArtigo
dcterms.licensehttp://www.nature.com/authors/policies/license.html
dspace.entity.typePublication
unesp.author.lattes8344823760633809[7]
unesp.author.orcid0000-0002-3250-8891[7]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
unesp.departmentBioquímica e Tecnologia - IQpt

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Araraquara - IQAR - Instituto de Química