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Synthesis of potentially bioactive PABA-related N-(aminoalkyl)lactamic amino acids and esters via selective SNAr reactions

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dc.contributor.authorGoncalves, Renato S. [UNESP]
dc.contributor.authorAbdelnur, Patricia V.
dc.contributor.authorSantos, Vanessa G.
dc.contributor.authorSimas, Rosineide C.
dc.contributor.authorEberlin, Marcos N.
dc.contributor.authorMagalhaes, Alvicler
dc.contributor.authorPerez Gonzalez, Eduardo R. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2014-05-20T13:23:01Z
dc.date.available2014-05-20T13:23:01Z
dc.date.issued2011-01-01
dc.description.abstractPotentially bioactive N-(aminoalkyl)lactamic amino acids and esters were synthesized in satisfactory to good yields by SNAr reactions of aromatic acids with N-(3-aminopropyl)lactams followed by esterification with tertiary amino alcohols. The addition-elimination SNAr mechanism was confirmed by NMR and MS measurements.en
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias & Tecnol, Dept Fis Quim & Biol, Lab Quim Organ Fina, BR-19060900 Presidente Prudente, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Programa Posgrad Ciência & Tecnol Mat POSMAT, São Paulo, Brazil
dc.description.affiliationUniv Estadual Campinas, UNICAMP, Inst Quim, Lab ThoMSon Espectrometria Massas, Campinas, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, UNICAMP, Inst Quim, Dept Quim Inorgan, Campinas, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias & Tecnol, Dept Fis Quim & Biol, Lab Quim Organ Fina, BR-19060900 Presidente Prudente, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Programa Posgrad Ciência & Tecnol Mat POSMAT, São Paulo, Brazil
dc.format.extent197-204
dc.identifierhttp://dx.doi.org/10.1007/s00726-010-0634-z
dc.identifier.citationAmino Acids. New York: Springer, v. 40, n. 1, p. 197-204, 2011.
dc.identifier.doi10.1007/s00726-010-0634-z
dc.identifier.issn0939-4451
dc.identifier.urihttp://hdl.handle.net/11449/6863
dc.identifier.wosWOS:000285781000018
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofAmino Acids
dc.relation.ispartofjcr2.906
dc.relation.ispartofsjr1,135
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectPABA derivativesen
dc.subjectLactamsen
dc.subjectPotential bio-activityen
dc.subjectSNAr reactionen
dc.titleSynthesis of potentially bioactive PABA-related N-(aminoalkyl)lactamic amino acids and esters via selective SNAr reactionsen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
dspace.entity.typePublication
unesp.author.orcid0000-0001-7439-8400[6]
unesp.author.orcid0000-0002-2018-0403[4]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências e Tecnologia, Presidente Prudentept
unesp.departmentFísica, Química e Biologia - FCTpt

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Presidente Prudente - FCT - Faculdade de Ciências e Tecnologia