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Anti-inflammatory and analgesic evaluation of hydroalcoholic extract and fractions from seeds of Piper cubeba L. (Piperaceae)

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dc.contributor.authorPerazzo, F. F.
dc.contributor.authorRodrigues, I. V.
dc.contributor.authorMaistro, Edson Luis [UNESP]
dc.contributor.authorSouza, S. M.
dc.contributor.authorNanaykkara, N. P. D.
dc.contributor.authorBastos, J. K.
dc.contributor.authorCarvalho, J. C. T.
dc.contributor.authorSouza, G. H. B. de
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversity of Mississippi
dc.contributor.institutionUniversidade Federal de Ouro Preto (UFOP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:29:32Z
dc.date.available2014-05-27T11:29:32Z
dc.date.issued2013-05-28
dc.description.abstractSome of the Piper species have been applied for the treatment of several diseases (anti-oxidant, antimicrobial, anti-inflammatory, and analgesic), considering multiple applications used in traditional medicine of different countries. About these, the present study evaluated some biological activities of Piper cubeba, as writhing test induced by acetic acid, ear edema induced by croton oil and paw edema induced by carrageenan were used by evaluated the analgesic and anti-inflammatory activities of crude hydroalcoholic extract (PCE) and its fractions of different polarities of P. cubeba L. seeds. The lethal dose (LD50) and the effective dose (ED50) were evaluated too. Both the PCE and dichloromethane fraction showed decrease values of edema and abdominal constrictions. The results obtained in this study confirm the low toxicity and analgesic and anti-inflammatory activities of PCE from P. cubeba seeds, justifying its use in folk medicine. Copyright © 2013, Phcog.Net, Published by Reed Elsevier India Pvt. Ltd. All rights reserved.en
dc.description.affiliationFaculdade de Ciências Farmacêuticas de Ribeirão Preto USP, Ribeirão Preto, SP, CEP 14040-903
dc.description.affiliationDepartamento de Ciências Exatas e da Terra UNIFESP, Diadema, SP, CEP 09972-270
dc.description.affiliationNational Center for Natural Products Research School of Pharmacy University of Mississippi, MS 38677
dc.description.affiliationLab. de Farmacognosia Escola de Farmácia UFOP, Ouro Preto, MG, CEP 35400-000
dc.description.affiliationFaculdade de Filosofia e Ciências Departamento de Fonoaudiologia UNESP, Marília, SP, CEP 17525-900
dc.description.affiliationUnespFaculdade de Filosofia e Ciências Departamento de Fonoaudiologia UNESP, Marília, SP, CEP 17525-900
dc.format.extent13-16
dc.identifierhttp://dx.doi.org/10.1016/j.phcgj.2012.12.001
dc.identifier.citationPharmacognosy Journal, v. 5, n. 1, p. 13-16, 2013.
dc.identifier.doi10.1016/j.phcgj.2012.12.001
dc.identifier.issn0975-3575
dc.identifier.lattes4787521613038315
dc.identifier.orcid0000-0003-0757-7876
dc.identifier.scopus2-s2.0-84878054430
dc.identifier.urihttp://hdl.handle.net/11449/75442
dc.language.isoeng
dc.relation.ispartofPharmacognosy Journal
dc.relation.ispartofsjr0,176
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAnalgesic
dc.subjectAnti-inflammatory
dc.subjectPiper cubeba
dc.subjectPiperaceae
dc.subjectacetic acid
dc.subjectacetic acid ethyl ester
dc.subjectalcohol
dc.subjectanalgesic agent
dc.subjectantiinflammatory agent
dc.subjectcarrageenan
dc.subjectcroton oil
dc.subjectdexamethasone
dc.subjectdichloromethane
dc.subjecthexane
dc.subjectindometacin
dc.subjectPiper cubeba extract
dc.subjectplant extract
dc.subjectsodium chloride
dc.subjectunclassified drug
dc.subjectanalgesic activity
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectantiinflammatory activity
dc.subjectcontrolled study
dc.subjectdrug efficacy
dc.subjectear edema
dc.subjectLD 50
dc.subjectmale
dc.subjectmouse
dc.subjectnonhuman
dc.subjectpain
dc.subjectpaw edema
dc.subjectplant seed
dc.subjectrat
dc.subjectsingle drug dose
dc.subjecttoxicity testing
dc.subjectwrithing test
dc.titleAnti-inflammatory and analgesic evaluation of hydroalcoholic extract and fractions from seeds of Piper cubeba L. (Piperaceae)en
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dspace.entity.typePublication
unesp.author.lattes4787521613038315[3]
unesp.author.orcid0000-0003-0757-7876[3]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Filosofia e Ciências, Maríliapt
unesp.departmentFonoaudiologia - FFCpt

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Marília - FFC - Faculdade de Filosofia e Ciências