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Study of Salmonella typhimurium mutagenicity assay of (E)-piplartine by the Ames test

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dc.contributor.authorMorandim-Giannetti, Andreia de A.
dc.contributor.authorCotinguiba, Fernando
dc.contributor.authorRegasini, Luis O.
dc.contributor.authorFrigieri, Mariana C. [UNESP]
dc.contributor.authorVaranda, Eliana Aparecida [UNESP]
dc.contributor.authorCoqueiro, Aline
dc.contributor.authorKato, Massuo J.
dc.contributor.authorBolzani, Vanderlan da Silva [UNESP]
dc.contributor.authorFurlan, Maysa [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionCtr Univ FEI
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T14:20:48Z
dc.date.available2014-05-20T14:20:48Z
dc.date.issued2011-06-15
dc.description.abstractPhytochemical studies carried out with Piperaceae species have shown great diversity of secondary metabolites among which are several displayed considerable biological activities. The species Piper tuberculatum has been intensively investigated and a series of amides have been described. For instance, (E)-piplartine showed significant cytotoxic activity against tumor cell lines, especially human leukemia cell lines; antifungal activity against Cladosporium species; trypanocidal activity and others. Considering the popular use of P. tuberculatum and the lack of pharmacological studies regarding this plant species, the mutagenic and antimutagenic effect of (E)-piplartine was evaluated by the Ames test, using the strains TA97a, TA98, TA100 and TA102 of Salmonella typhimurium. No mutagenic activity was observed for this compound.en
dc.description.affiliationUniv Estadual São Paulo, Inst Quim, Dept Quim Organ, BR-14800900 Araraquara, SP, Brazil
dc.description.affiliationCtr Univ FEI, Dept Engn Quim, BR-09850901 Sao Bernardo do Campo, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias Farmaceut, Dept Ciencias Biol, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUniv São Paulo, Inst Quim, Dept Quim Fundamental, BR-05508000 São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias Farmaceut, Dept Ciencias Biol, BR-14801902 Araraquara, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent5398-5401
dc.identifierhttp://www.ajol.info/index.php/ajb/article/view/94310
dc.identifier.citationAfrican Journal of Biotechnology. Victoria Island: Academic Journals, v. 10, n. 27, p. 5398-5401, 2011.
dc.identifier.fileWOS000294614400021.pdf
dc.identifier.issn1684-5315
dc.identifier.lattes7501930236496670
dc.identifier.lattes1308042794786872
dc.identifier.urihttp://hdl.handle.net/11449/26248
dc.identifier.wosWOS:000294614400021
dc.language.isoeng
dc.publisherAcademic Journals
dc.relation.ispartofAfrican Journal of Biotechnology
dc.rights.accessRightsAcesso abertopt
dc.sourceWeb of Science
dc.subjectPiperaceaeen
dc.subjectPiper tuberculatumen
dc.subject(Z)-piplartineen
dc.subjectmutagenic activateden
dc.subjectAmes testen
dc.titleStudy of Salmonella typhimurium mutagenicity assay of (E)-piplartine by the Ames testen
dc.typeArtigopt
dcterms.licensehttp://www.academicjournals.org/Creative%20Common%20Attribution%20License.htm
dcterms.rightsHolderAcademic Journals
dspace.entity.typePublication
relation.isDepartmentOfPublication5004bcab-94af-4939-b980-091ae9d0a19e
relation.isDepartmentOfPublication.latestForDiscovery5004bcab-94af-4939-b980-091ae9d0a19e
relation.isOrgUnitOfPublication95697b0b-8977-4af6-88d5-c29c80b5ee92
relation.isOrgUnitOfPublication.latestForDiscovery95697b0b-8977-4af6-88d5-c29c80b5ee92
unesp.author.lattes7501930236496670
unesp.author.lattes1308042794786872
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentCiências Biológicas - FCFpt

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