Publication: Further bioactive piperidine alkaloids from the flowers and green fruits of Cassia spectabilis
Loading...
Date
Advisor
Coadvisor
Graduate program
Undergraduate course
Journal Title
Journal ISSN
Volume Title
Publisher
Amer Chemical Soc
Type
Article
Access right
Acesso restrito
Abstract
The flowers of Cassia spectabilis yielded three new piperidine alkaloids, (-)-3-O-acetylspectaline (1), (-)-7-hydroxyspectaline (2), and iso-6-spectaline (3), together with the known (-)-spectaline (4). The green fruits of this plant were also investigated, resulting in the isolation of 1 and 4. Their structures were elucidated using a combination of multidimensional NMR and MS techniques, and relative stereochemistries were established by NOESY correlations and analysis of coupling constants. The DNA-damaging activity of these compounds was evaluated using a mutant yeast, Saccharomyces cerevisiae, assay.
Description
Keywords
Language
English
Citation
Journal of Natural Products. Washington: Amer Chemical Soc, v. 67, n. 5, p. 908-910, 2004.
