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Further bioactive piperidine alkaloids from the flowers and green fruits of Cassia spectabilis

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dc.contributor.authorViegas, C.
dc.contributor.authorBolzani, Vanderlan da Silva [UNESP]
dc.contributor.authorFurlan, Maysa [UNESP]
dc.contributor.authorBarreiro, E. J.
dc.contributor.authorYoung, MCM
dc.contributor.authorTomazela, D.
dc.contributor.authorEberlin, M. N.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionInst Bot
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2014-05-20T15:20:02Z
dc.date.available2014-05-20T15:20:02Z
dc.date.issued2004-05-01
dc.description.abstractThe flowers of Cassia spectabilis yielded three new piperidine alkaloids, (-)-3-O-acetylspectaline (1), (-)-7-hydroxyspectaline (2), and iso-6-spectaline (3), together with the known (-)-spectaline (4). The green fruits of this plant were also investigated, resulting in the isolation of 1 and 4. Their structures were elucidated using a combination of multidimensional NMR and MS techniques, and relative stereochemistries were established by NOESY correlations and analysis of coupling constants. The DNA-damaging activity of these compounds was evaluated using a mutant yeast, Saccharomyces cerevisiae, assay.en
dc.description.affiliationUniv Estadual Paulista, UNESP, Inst Quim, BR-14800900 Araraquara, SP, Brazil
dc.description.affiliationUniv Fed Rio de Janeiro, Fac Farm, BR-21944190 Rio de Janeiro, Brazil
dc.description.affiliationInst Bot, IBt, Seccao Fisiol & Bioquim Plantas, BR-01061970 São Paulo, Brazil
dc.description.affiliationUniv Estadual Campinas, Inst Quim, UNICAMP, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Inst Quim, BR-14800900 Araraquara, SP, Brazil
dc.format.extent908-910
dc.identifierhttp://dx.doi.org/10.1021/np0303963
dc.identifier.citationJournal of Natural Products. Washington: Amer Chemical Soc, v. 67, n. 5, p. 908-910, 2004.
dc.identifier.doi10.1021/np0303963
dc.identifier.issn0163-3864
dc.identifier.lattes4484083685251673
dc.identifier.lattes1308042794786872
dc.identifier.urihttp://hdl.handle.net/11449/31389
dc.identifier.wosWOS:000221804700034
dc.language.isoeng
dc.publisherAmer Chemical Soc
dc.relation.ispartofJournal of Natural Products
dc.relation.ispartofjcr3.885
dc.relation.ispartofsjr1,368
dc.rights.accessRightsAcesso restritopt
dc.sourceWeb of Science
dc.titleFurther bioactive piperidine alkaloids from the flowers and green fruits of Cassia spectabilisen
dc.typeArtigopt
dcterms.licensehttp://pubs.acs.org/paragonplus/copyright/jpa_form_a.pdf
dcterms.rightsHolderAmer Chemical Soc
dspace.entity.typePublication
relation.isOrgUnitOfPublicationbc74a1ce-4c4c-4dad-8378-83962d76c4fd
relation.isOrgUnitOfPublication.latestForDiscoverybc74a1ce-4c4c-4dad-8378-83962d76c4fd
unesp.author.lattes4484083685251673
unesp.author.lattes1308042794786872
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
unesp.departmentQuímica Orgânica - IQARpt

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Araraquara - IQAR - Instituto de Química