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The prodrug approach: A successful tool for improving drug solubility

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dc.contributor.authorJornada, Daniela Hartmann [UNESP]
dc.contributor.authorDos Santos Fernandes, Guilherme Felipe [UNESP]
dc.contributor.authorChiba, Diego Eidy [UNESP]
dc.contributor.authorDe Melo, Thais Regina Ferreira [UNESP]
dc.contributor.authorDos Santos, Jean Leandro [UNESP]
dc.contributor.authorChung, Man Chin [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T16:44:51Z
dc.date.available2018-12-11T16:44:51Z
dc.date.issued2016-01-01
dc.description.abstractProdrug design is a widely known molecular modification strategy that aims to optimize the physicochemical and pharmacological properties of drugs to improve their solubility and pharmacokinetic features and decrease their toxicity. A lack of solubility is one of the main obstacles to drug development. This review aims to describe recent advances in the improvement of solubility via the prodrug approach. The main chemical carriers and examples of successful strategies will be discussed, highlighting the advances of this field in the last ten years.en
dc.description.affiliationFaculdade de Ciências Farmacêuticas UNESP-University Estadual Paulista, Rodovia Araraquara Jaú Km 01
dc.description.affiliationUnespFaculdade de Ciências Farmacêuticas UNESP-University Estadual Paulista, Rodovia Araraquara Jaú Km 01
dc.identifierhttp://dx.doi.org/10.3390/molecules21010042
dc.identifier.citationMolecules, v. 21, n. 1, 2016.
dc.identifier.doi10.3390/molecules21010042
dc.identifier.file2-s2.0-85000542430.pdf
dc.identifier.issn1420-3049
dc.identifier.lattes9734333607975413
dc.identifier.orcid0000-0003-4141-0455
dc.identifier.scopus2-s2.0-85000542430
dc.identifier.urihttp://hdl.handle.net/11449/169189
dc.language.isoeng
dc.relation.ispartofMolecules
dc.relation.ispartofsjr0,855
dc.rights.accessRightsAcesso abertopt
dc.sourceScopus
dc.subjectMolecular modification
dc.subjectProdrug
dc.subjectSolubility
dc.subjectSolubility of prodrugs
dc.subjectWater-soluble prodrugs
dc.titleThe prodrug approach: A successful tool for improving drug solubilityen
dc.typeResenhapt
dspace.entity.typePublication
relation.isOrgUnitOfPublication95697b0b-8977-4af6-88d5-c29c80b5ee92
relation.isOrgUnitOfPublication.latestForDiscovery95697b0b-8977-4af6-88d5-c29c80b5ee92
unesp.author.lattes9734333607975413[6]
unesp.author.orcid0000-0003-4141-0455[6]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas