Publicação: Nitric oxide release using natural rubber latex as matrix
dc.contributor.author | Herculano, Rondinelli Donizetti [UNESP] | |
dc.contributor.author | Tzu, Lee Chen | |
dc.contributor.author | Silva, Cecilia Pereira | |
dc.contributor.author | Brunello, Carlos Alberto | |
dc.contributor.author | Queiroz, Álvaro Antônio Alencar de | |
dc.contributor.author | Kinoshita, Angela | |
dc.contributor.author | Graeff, Carlos Frederico de Oliveira [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Universidade Sagrado Coração | |
dc.contributor.institution | Universidade de São Paulo (USP) | |
dc.contributor.institution | Universidade Federal de Itajubá (UNIFEI) | |
dc.date.accessioned | 2014-05-20T13:22:18Z | |
dc.date.available | 2014-05-20T13:22:18Z | |
dc.date.issued | 2011-09-01 | |
dc.description.abstract | Nitric oxide (NO) is a diffusible messenger that has been involved in numerous physiological processes ranging from vasodilatation and antimicrobial properties to wound healing. The beneficial effects can be attributed to the role NO plays in angiogenesis, inflammation and tissue remodeling. In the present work, a polymeric device for the sustained site specific delivery of nitric oxide using a latex rubber matrix from Hevea brasiliensis which encapsulates the spin trap iron(II)- diethyldithiocarbamate complex (FeDETC) was developed. The release profiles of NO from latex rubber matrix were studied and stability studies were carried out. Electron Paramagnetic Resonance (EPR) signal of NO was detected in the membrane exposed to ambient atmosphere at room temperature (25 °C) even after 350 hours. FTIR spectroscopy data indicated that NO-FeDETC retained its structural and spectroscopic properties upon encapsulation in the latex matrix. The NO delivery system developed in this work as a membrane, presented high stability. | en |
dc.description.affiliation | UNESP Faculdade de Ciências e Letras de Assis Departamento de Ciências Biológicas | |
dc.description.affiliation | Universidade Sagrado Coração | |
dc.description.affiliation | USP Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto Departamento de Física e Matemática | |
dc.description.affiliation | Universidade Federal de Itajubá Departamento de Física e Química | |
dc.description.affiliation | UNESP Faculdade de Ciências Departamento de Física | |
dc.description.affiliationUnesp | UNESP Faculdade de Ciências e Letras de Assis Departamento de Ciências Biológicas | |
dc.description.affiliationUnesp | UNESP Faculdade de Ciências Departamento de Física | |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
dc.format.extent | 355-359 | |
dc.identifier | http://dx.doi.org/10.1590/S1516-14392011005000055 | |
dc.identifier.citation | Materials Research. ABM, ABC, ABPol, v. 14, n. 3, p. 355-359, 2011. | |
dc.identifier.doi | 10.1590/S1516-14392011005000055 | |
dc.identifier.file | S1516-14392011000300012.pdf | |
dc.identifier.issn | 1516-1439 | |
dc.identifier.orcid | 0000-0003-0162-8273 | |
dc.identifier.scielo | S1516-14392011000300012 | |
dc.identifier.uri | http://hdl.handle.net/11449/6526 | |
dc.identifier.wos | WOS:000296277000012 | |
dc.language.iso | eng | |
dc.publisher | ABM, ABC, ABPol | |
dc.relation.ispartof | Materials Research | |
dc.relation.ispartofjcr | 1.103 | |
dc.relation.ispartofsjr | 0,398 | |
dc.rights.accessRights | Acesso aberto | |
dc.source | SciELO | |
dc.subject | nitric oxide | en |
dc.subject | latex membrane | en |
dc.subject | biomaterials | en |
dc.subject | drug delivery system | en |
dc.title | Nitric oxide release using natural rubber latex as matrix | en |
dc.type | Artigo | |
dcterms.license | http://www.scielo.br/revistas/mr/paboutj.htm | |
dspace.entity.type | Publication | |
unesp.author.lattes | 5268607684223281[7] | |
unesp.author.orcid | 0000-0003-0162-8273[7] | |
unesp.campus | Universidade Estadual Paulista (UNESP), Faculdade de Ciências e Letras, Assis | pt |
unesp.campus | Universidade Estadual Paulista (UNESP), Faculdade de Ciências, Bauru | pt |
unesp.department | Física - FC | pt |
unesp.department | Ciências Biológicas - FCLAS | pt |
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