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Cytotoxic Clerodane Diterpenes from Casearia rupestris

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dc.contributor.authorVieira-Junior, Gerardo M. [UNESP]
dc.contributor.authorDutra, Luiz A. [UNESP]
dc.contributor.authorFerreira, Paulo M. P.
dc.contributor.authorde Moraes, Manoel O.
dc.contributor.authorLotufo, Leticia V. Costa
dc.contributor.authorPessoa, Claudia do O.
dc.contributor.authorTorres, Roseli Buzanelli
dc.contributor.authorBoralle, Nivaldo [UNESP]
dc.contributor.authorBolzani, Vanderlan da Silva [UNESP]
dc.contributor.authorCavalheiro, Alberto José [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal do Piauí (UFPI)
dc.contributor.institutionUniversidade Federal do Ceará (UFC)
dc.contributor.institutionInstituto Agronômico (IAC)
dc.date.accessioned2014-05-20T14:20:16Z
dc.date.available2014-05-20T14:20:16Z
dc.date.issued2011-04-01
dc.description.abstractFour new clerodane diterpenes, casearupestrins A-D (1-4), were isolated from the leaves of Casearia rupestris. Compounds 1 and 4 were acetylated to yield 2,7-di-O-acetylcasearupestrin A (5) and 2,6-di-O-acetylcasearupestrin D (6), All compounds were evaluated for cytotoxicity against a small panel of human cancer cell lines. Caseartipestrin A (1) exhibited the most potent activity against MDA/MB-435 (human Melanoma) and SF-295 (human glioblastoma) cells, superior to that of the standard drug:doxorubicin.en
dc.description.affiliationSão Paulo State Univ, UNESP, Inst Chem, Nucley Bioassay Biosynth & Ecophysiol Nat Prod Nu, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationUniv Fed Piaui, UFPI, Dept Ciencias Saude, BR-64600000 Picos, PI, Brazil
dc.description.affiliationUniversidade Federal do Ceará (UFC), Dept Fisiol & Farmacol, Lab Oncol Expt LOE, BR-60430270 Fortaleza, Ceara, Brazil
dc.description.affiliationInstituto Agronômico de Campinas, Nucleo Jardim Bot, Campinas, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Inst Chem, Nucley Bioassay Biosynth & Ecophysiol Nat Prod Nu, BR-14801970 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipBiota Instituto Virtual da Biodiversidade
dc.description.sponsorshipIdFAPESP: 03/02176-7
dc.format.extent776-781
dc.identifierhttp://dx.doi.org/10.1021/np100840w
dc.identifier.citationJournal of Natural Products. Washington: Amer Chemical Soc, v. 74, n. 4, p. 776-781, 2011.
dc.identifier.doi10.1021/np100840w
dc.identifier.issn0163-3864
dc.identifier.urihttp://hdl.handle.net/11449/26092
dc.identifier.wosWOS:000289742300036
dc.language.isoeng
dc.publisherAmer Chemical Soc
dc.relation.ispartofJournal of Natural Products
dc.relation.ispartofjcr3.885
dc.relation.ispartofsjr1,368
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleCytotoxic Clerodane Diterpenes from Casearia rupestrisen
dc.typeArtigo
dcterms.licensehttp://pubs.acs.org/page/policy/nih/index.html
dcterms.rightsHolderAmer Chemical Soc
dspace.entity.typePublication
unesp.author.lattes2518006820764120[10]
unesp.author.orcid0000-0001-8214-9957[10]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araraquarapt
unesp.departmentFisiologia e Patologia - FOARpt

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Araraquara - FOAR - Faculdade de Odontologia