Histomorphometric analysis of homogenous demineralized dentin matrix as osteopromotive material in rabbit mandibles
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Purpose: The aim of this work was to evaluate the effectiveness of homogenous demineralized dentin matrix (HDDM) slices in surgical bone defects created in the mandibles of rabbits and occluded with a polytetrafluoroethylene (PTFE) membrane in the promotion of bone growth. Materials and Methods: Surgical bone defects were created in 36 adult rabbits and divided into 4 groups: bone defect (control), bone defect with PTFE membrane, bone defect with HDDM, and bone defect with both HDDM and a PTFE membrane (HDDM + PTFE). The rabbits were sacrificed after 30, 60, and 90 days, and the bone defects were examined histologically and by histomorphometric analysis (analysis of variance and the Tukey test). Results: The volume of newly formed bone matrix was significantly greater in the HDDM and HDDM + PTFE groups than in the control and PTFE groups. The discrete inflammatory reaction found in the HDDM and HDDM + PTFE groups did not prevent the osteopromotive activity of the dentin matrix. Discussion: HDDM slices were biocompatible and were resorbed during the bone remodeling process. They stimulated the newly formed bone until 30 days after implantation. Conclusion: Bone repair was accelerated in the bone defects treated with HDDM in comparison to the control group.
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Bone repair , Guided tissue regeneration , Homogenous demineralized dentin matrix , Osteopromotion , Tissue engineering , anesthetic agent , antibiotic agent , diclofenac , ketamine , pentabiotic , pentabiotico , politef , rompum , unclassified drug , analysis of variance , animal experiment , animal model , animal tissue , bone demineralization , bone growth , bone matrix , bone remodeling , controlled study , dentin , evaluation , examination , histology , inflammation , jaw malformation , mandible , membrane , morphometrics , nonhuman , osteolysis , rabbit , stimulation , tooth implantation , tooth occlusion , Analysis of Variance , Animals , Biocompatible Materials , Bone Matrix , Bone Remodeling , Bone Substitutes , Dental Materials , Dentin , Guided Tissue Regeneration , Haversian System , Mandibular Diseases , Membranes, Artificial , Osteogenesis , Polytetrafluoroethylene , Rabbits , Time Factors
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International Journal of Oral and Maxillofacial Implants, v. 19, n. 5, p. 679-686, 2004.
