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Cell death and quantitative reduction of rests of Malassez according to age

dc.contributor.authorGoncalves, J. S. [UNESP]
dc.contributor.authorSasso-Cerri, E. [UNESP]
dc.contributor.authorCerri, Paulo Sérgio [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:46:48Z
dc.date.available2014-05-20T13:46:48Z
dc.date.issued2008-08-01
dc.description.abstractBackground and Objective: Rests of Malassez are clusters of epithelial cells that remain in the periodontal ligament throughout life. However, it has been reported that the number of these structures decreases with age, and some epithelial cells undergo apoptosis in rests of Malassez of young and adult rats. Therefore, the purpose of the present study was to investigate the incidence of epithelial cell death and the quantitative changes in the rests of Malassez in rat molars of different ages.Material and Methods: Fragments containing the upper molars of rats aged 29, 45 and 120 d were fixed, decalcified and embedded for analysis by light microscopy. In the sections stained by hematoxylin and eosin, the number of rests of Malassez and the number of nuclei of these epithelial structures were obtained. Moreover, the nuclei exhibiting typical features of cell death were also counted in each rest of Malassez. The terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) method for detection of cell death was also carried out.Results: In all groups examined, some rests of Malassez exhibited epithelial cell nuclei with typical features of apoptosis and some of them were also TUNEL positive. From 29 to 120 d of age in rats, the quantitative analysis showed a significant decrease in the total number of rests of Malassez in the cervical, middle and furcation regions of the periodontal ligament. Moreover, a significant decrease of epithelial cell nuclei was concomitant to an increase in the frequency of cell death in the oldest rats.Conclusion: These results suggest that epithelial cell death by apoptosis may be, at least in part, responsible for the reduction in the number of rests of Malassez according to age.en
dc.description.affiliationUNESP, Sch Dent, Dept Morphol, Lab Histol & Embryol, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, Sch Dent, Dept Morphol, Lab Histol & Embryol, BR-14801903 Araraquara, SP, Brazil
dc.format.extent478-481
dc.identifierhttp://dx.doi.org/10.1111/j.1600-0765.2007.01050.x
dc.identifier.citationJournal of Periodontal Research. Malden: Wiley-blackwell, v. 43, n. 4, p. 478-481, 2008.
dc.identifier.doi10.1111/j.1600-0765.2007.01050.x
dc.identifier.issn0022-3484
dc.identifier.lattes3278495911207882
dc.identifier.orcid0000-0001-5756-5828
dc.identifier.urihttp://hdl.handle.net/11449/16587
dc.identifier.wosWOS:000256921300014
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal of Periodontal Research
dc.relation.ispartofjcr2.878
dc.relation.ispartofsjr0,927
dc.rights.accessRightsAcesso restritopt
dc.sourceWeb of Science
dc.subjectapoptosisen
dc.subjectepithelial cellsen
dc.subjectmorphometryen
dc.subjectperiodontiumen
dc.subjectrests of Malassezen
dc.titleCell death and quantitative reduction of rests of Malassez according to ageen
dc.typeArtigopt
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-blackwell
dspace.entity.typePublication
relation.isOrgUnitOfPublicationca4c0298-cd82-48ee-a9c8-c97704bac2b0
relation.isOrgUnitOfPublication.latestForDiscoveryca4c0298-cd82-48ee-a9c8-c97704bac2b0
unesp.author.lattes3278495911207882[3]
unesp.author.orcid0000-0001-5756-5828[3]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araraquarapt
unesp.departmentMorfologia - FOARpt

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