Publicação: Interleukin-6 polymorphism and Helicobacter pylori infection in Brazilian adult patients with chronic gastritis
dc.contributor.author | Gatti, L. L. | |
dc.contributor.author | Tunes, M. Z. | |
dc.contributor.author | Labio, R. W. de | |
dc.contributor.author | Silva, L. C. | |
dc.contributor.author | Smith, MDC | |
dc.contributor.author | Payo, SLM | |
dc.contributor.institution | Fac Med Marila | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Univ Sagrado Coracao USC Bauru | |
dc.date.accessioned | 2015-03-18T15:53:01Z | |
dc.date.available | 2015-03-18T15:53:01Z | |
dc.date.issued | 2005-10-01 | |
dc.description.abstract | Helicobacter pylori is recognised as the most common cause of chronic active gastritis and this bacterium is also an important pathogenic factor in peptic ulcer disease. The biological factors that influence clinical outcome in H. pylori infection have been extensively studied. In addition to immunological factors in the host, bacterial virulence determinants in H. pylori strains are likely to play a crucial role in gastric cancer development. Single-nucleotide polymorphisms at the 5' flanking region of the interleukin (IL)-6 gene promoter (G or C at -174 base) have been identified and individuals with the G allele at position -174 have been shown to produce higher levels of IL-6 than those with the C/C genotype. The mucosal levels of IL-6 were reported to be increased in H. pylori-associated gastritis. The present study was conducted to examine any relationship between inflammatory cytokine polymorphisms and the inflammatory process in mucosa infected by H. pylori. In our study we did not find any association between the C and G alleles in adult patients with chronic gastritis and inflammatory process in gastric mucosa. | en |
dc.description.affiliation | Fac Med Marila, Hemoctr, Disciplina Genet & Biol Mol, BR-17519050 Sao Paulo, Brazil | |
dc.description.affiliation | Fac Med Marila, Lab Citogenet & Biol Mol, Sao Paulo, Brazil | |
dc.description.affiliation | Univ Fed Sao Paulo, UNESP, Disciplina Genet, Sao Paulo, Brazil | |
dc.description.affiliation | Fac Med Marila, Aluno Curso Med, Sao Paulo, Brazil | |
dc.description.affiliation | Fac Med Marila, Disciplina Patol, Sao Paulo, Brazil | |
dc.description.affiliation | Univ Sagrado Coracao USC Bauru, Mestrado Biool Oral, Sao Paulo, Brazil | |
dc.description.affiliationUnesp | Univ Fed Sao Paulo, UNESP, Disciplina Genet, Sao Paulo, Brazil | |
dc.format.extent | 112-116 | |
dc.identifier | http://dx.doi.org/10.1007/s10238-005-0074-3 | |
dc.identifier.citation | Clinical And Experimental Medicine. New York: Springer, v. 5, n. 3, p. 112-116, 2005. | |
dc.identifier.doi | 10.1007/s10238-005-0074-3 | |
dc.identifier.issn | 1591-8890 | |
dc.identifier.uri | http://hdl.handle.net/11449/116292 | |
dc.identifier.wos | WOS:000233117500004 | |
dc.language.iso | eng | |
dc.publisher | Springer | |
dc.relation.ispartof | Clinical And Experimental Medicine | |
dc.relation.ispartofjcr | 2.787 | |
dc.relation.ispartofsjr | 0,848 | |
dc.rights.accessRights | Acesso restrito | |
dc.source | Web of Science | |
dc.subject | Helicobacter pylori | en |
dc.subject | interleukin-6 polymorphism | en |
dc.subject | gastritis | en |
dc.title | Interleukin-6 polymorphism and Helicobacter pylori infection in Brazilian adult patients with chronic gastritis | en |
dc.type | Artigo | |
dcterms.license | http://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0 | |
dcterms.rightsHolder | Springer | |
dspace.entity.type | Publication | |
unesp.author.orcid | 0000-0002-1441-1033[5] |