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Interleukin-6 polymorphism and Helicobacter pylori infection in Brazilian adult patients with chronic gastritis

dc.contributor.authorGatti, L. L.
dc.contributor.authorTunes, M. Z.
dc.contributor.authorLabio, R. W. de
dc.contributor.authorSilva, L. C.
dc.contributor.authorSmith, MDC
dc.contributor.authorPayo, SLM
dc.contributor.institutionFac Med Marila
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Sagrado Coracao USC Bauru
dc.date.accessioned2015-03-18T15:53:01Z
dc.date.available2015-03-18T15:53:01Z
dc.date.issued2005-10-01
dc.description.abstractHelicobacter pylori is recognised as the most common cause of chronic active gastritis and this bacterium is also an important pathogenic factor in peptic ulcer disease. The biological factors that influence clinical outcome in H. pylori infection have been extensively studied. In addition to immunological factors in the host, bacterial virulence determinants in H. pylori strains are likely to play a crucial role in gastric cancer development. Single-nucleotide polymorphisms at the 5' flanking region of the interleukin (IL)-6 gene promoter (G or C at -174 base) have been identified and individuals with the G allele at position -174 have been shown to produce higher levels of IL-6 than those with the C/C genotype. The mucosal levels of IL-6 were reported to be increased in H. pylori-associated gastritis. The present study was conducted to examine any relationship between inflammatory cytokine polymorphisms and the inflammatory process in mucosa infected by H. pylori. In our study we did not find any association between the C and G alleles in adult patients with chronic gastritis and inflammatory process in gastric mucosa.en
dc.description.affiliationFac Med Marila, Hemoctr, Disciplina Genet & Biol Mol, BR-17519050 Sao Paulo, Brazil
dc.description.affiliationFac Med Marila, Lab Citogenet & Biol Mol, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, UNESP, Disciplina Genet, Sao Paulo, Brazil
dc.description.affiliationFac Med Marila, Aluno Curso Med, Sao Paulo, Brazil
dc.description.affiliationFac Med Marila, Disciplina Patol, Sao Paulo, Brazil
dc.description.affiliationUniv Sagrado Coracao USC Bauru, Mestrado Biool Oral, Sao Paulo, Brazil
dc.description.affiliationUnespUniv Fed Sao Paulo, UNESP, Disciplina Genet, Sao Paulo, Brazil
dc.format.extent112-116
dc.identifierhttp://dx.doi.org/10.1007/s10238-005-0074-3
dc.identifier.citationClinical And Experimental Medicine. New York: Springer, v. 5, n. 3, p. 112-116, 2005.
dc.identifier.doi10.1007/s10238-005-0074-3
dc.identifier.issn1591-8890
dc.identifier.urihttp://hdl.handle.net/11449/116292
dc.identifier.wosWOS:000233117500004
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofClinical And Experimental Medicine
dc.relation.ispartofjcr2.787
dc.relation.ispartofsjr0,848
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectHelicobacter pylorien
dc.subjectinterleukin-6 polymorphismen
dc.subjectgastritisen
dc.titleInterleukin-6 polymorphism and Helicobacter pylori infection in Brazilian adult patients with chronic gastritisen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
dspace.entity.typePublication
unesp.author.orcid0000-0002-1441-1033[5]

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