Publicação: Epstein-Barr Virus microRNAs in the pathogenesis of human cancers
| dc.contributor.author | Caetano, Brunno Felipe Ramos | |
| dc.contributor.author | Jorge, Beatrice Adrianne Silva | |
| dc.contributor.author | Müller-Coan, Bárbara Grasiele | |
| dc.contributor.author | Oliveira, Deilson Elgui de [UNESP] | |
| dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
| dc.date.accessioned | 2020-12-14T13:16:31Z | |
| dc.date.available | 2020-12-14T13:16:31Z | |
| dc.date.issued | 2020-11 | |
| dc.description.abstract | The Epstein-Barr Virus (EBV) is a gamma-herpesvirus involved with a variety of human cancers, notably the endemic Burkitt lymphoma and nasopharyngeal carcinoma. In 2004, EBV was described as one the first known human oncoviruses to encode viral microRNAs (miRNAs), and these molecules were found to interact with viral and host targets. EBV miRNAs modulate biological processes that are critical for carcinogenesis, contributing to cell transformation and tumor progression of EBV-associated cancers. Herein we review and discuss EBV miRNAs as modulators of viral biology and carcinogenesis, as well as their usefulness as putative markers to monitor the onset, progression, and recurrence of cancers associated with the EBV infection. | en |
| dc.description.affiliation | São Paulo State University (UNESP), Medical School of Botucatu | |
| dc.description.affiliation | São Paulo State University (UNESP), Institute of Biosciences of Botucatu | |
| dc.description.affiliation | São Paulo State University (UNESP), Institute of Biotechnology (IBTEC) | |
| dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
| dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
| dc.description.sponsorshipId | FAPESP 2017/20352-0 (DR scholarship), 2017/22312-5 (DR scholarship), 2017/233393-9 (Research Grant), 2018/12164-1 (MSc scholarship), 2019/03804-0 (BEPE DR scholarship), 2019/05061-4 (BEPE MS scholarship) | |
| dc.description.sponsorshipId | CNPq 142294/2017-9 (DR scholarship) | |
| dc.description.version | Preprint | pt |
| dc.identifier.doi | 10.1016/j.canlet.2020.11.019 | |
| dc.identifier.issn | 0304-3835 | |
| dc.identifier.lattes | 5240998569868081 | |
| dc.identifier.orcid | 0000-0001-5562-9648 | |
| dc.identifier.uri | http://hdl.handle.net/11449/202118 | |
| dc.language.iso | eng | |
| dc.publisher | Elsevier | |
| dc.relation.ispartof | Cancer Letters | pt |
| dc.rights.accessRights | Acesso aberto | |
| dc.subject | EBV mir-BARTs | en |
| dc.subject | EBV mir-BHRF1 | en |
| dc.subject | EBERs | en |
| dc.subject | Nasopharyngeal carcinomas | en |
| dc.subject | Lymphomas | en |
| dc.subject | Gastric carcinomas | en |
| dc.title | Epstein-Barr Virus microRNAs in the pathogenesis of human cancers | en |
| dc.type | Artigo | |
| dspace.entity.type | Publication | |
| unesp.campus | Universidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatu | pt |
| unesp.department | Patologia - FMB | pt |
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