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Effects of the ethyl acetate fraction of Alchornea triplinervia on healing gastric ulcer in rats

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dc.contributor.authorLima, Zeila P. [UNESP]
dc.contributor.authorBonamin, Flavia [UNESP]
dc.contributor.authorCalvo, Tamara R. [UNESP]
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorSantos, Lourdes C. [UNESP]
dc.contributor.authorRozza, Ariane L. [UNESP]
dc.contributor.authorPellizzon, Claudia H. [UNESP]
dc.contributor.authorRocha, Lucia R. M. [UNESP]
dc.contributor.authorHiruma-Lima, Clélia A. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:26:07Z
dc.date.available2014-05-27T11:26:07Z
dc.date.issued2011-11-09
dc.description.abstractAlchornea triplinervia (Spreng.) Muell. Arg (Euphorbiaceae) is a medicinal plant commonly used by people living in the Cerrado region of Brazil to treat gastrointestinal ulcers. We previously described the gastroprotective action of methanolic extract (ME) of Alchornea triplinervia and the ethyl acetate fraction (EAF) in increasing of prostaglandin E 2 (PGE 2) gastric levels in the mucosa. In this work we evaluated the effect of EAF in promoting the healing process in rats with acetic acid-induced gastric ulcers. In addition, toxicity was investigated during treatment with EAF. After 14 days of treatment with EAF, the potent stimulator of gastric cell proliferation contributed to the acceleration of gastric ulcer healing. Upon immunohistochemical analysis, we observed a pronounced expression of COX-2, mainly in the submucosal layer. The 14-day EAF treatment also significantly increased the number of neutrophils in the gastric mucosa regeneration area. The EAF induced angiogenesis on gastric mucosa, observed as an increase of the number of blood vessels supplying the stomach in rats treated with EAF. Oral administration for 14 days of the ethyl acetate fraction from Alchornea triplinervia accelerated the healing of gastric ulcers in rats by promoting epithelial cell proliferation, increasing the number of neutrophils and stimulation of mucus production. This fraction, which contained mainly phenolic compounds, contributed to gastric mucosa healing. © 2011 by the authors; licensee MDPI, Basel, Switzerland.en
dc.description.affiliationDepartment of Physiology Univ. Estadual Paulista-UNESP, Rubião Junior, cp 510, CEP 18618-000, Botucatu, São Paulo
dc.description.affiliationInstitute of Chemistry Univ. Estadual Paulista-UNESP, cp 355, CEP 14801-970, Araraquara, São Paulo
dc.description.affiliationDepartment of Morphology Univ. Estadual Paulista-UNESP, cp 610, CEP 18618-000, UNESP, Botucatu, São Paulo
dc.description.affiliationUnespDepartment of Physiology Univ. Estadual Paulista-UNESP, Rubião Junior, cp 510, CEP 18618-000, Botucatu, São Paulo
dc.description.affiliationUnespInstitute of Chemistry Univ. Estadual Paulista-UNESP, cp 355, CEP 14801-970, Araraquara, São Paulo
dc.description.affiliationUnespDepartment of Morphology Univ. Estadual Paulista-UNESP, cp 610, CEP 18618-000, UNESP, Botucatu, São Paulo
dc.format.extent1423-1433
dc.identifierhttp://dx.doi.org/10.3390/ph4111423
dc.identifier.citationPharmaceuticals, v. 4, n. 11, p. 1423-1433, 2011.
dc.identifier.doi10.3390/ph4111423
dc.identifier.file2-s2.0-80455131271.pdf
dc.identifier.issn1424-8247
dc.identifier.lattes0019393779801069
dc.identifier.lattes3814504901386844
dc.identifier.orcid0000-0002-8645-3777
dc.identifier.orcid0000-0003-3032-2556
dc.identifier.orcid0000-0002-4494-4180
dc.identifier.scopus2-s2.0-80455131271
dc.identifier.urihttp://hdl.handle.net/11449/72789
dc.language.isoeng
dc.relation.ispartofPharmaceuticals
dc.relation.ispartofsjr1,293
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAlchornea triplinervia
dc.subjectAngiogenesis
dc.subjectEuphorbiaceae
dc.subjectHealing ulcer effect
dc.subjectPhenolic compounds
dc.subjectacetic acid ethyl ester
dc.subjectAlchornea triplinervia extract
dc.subjectantiulcer agent
dc.subjectcimetidine
dc.subjectcyclooxygenase 2
dc.subjectplant extract
dc.subjectunclassified drug
dc.subjectangiogenesis
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectcell proliferation
dc.subjectcontrolled study
dc.subjectdose response
dc.subjectdrug effect
dc.subjectdrug mechanism
dc.subjectdrug screening
dc.subjectEuphorbia
dc.subjectimmunohistochemistry
dc.subjectmale
dc.subjectmucus secretion
dc.subjectneutrophil count
dc.subjectnonhuman
dc.subjectplant leaf
dc.subjectprotein expression
dc.subjectrat
dc.subjectsingle drug dose
dc.subjectstomach mucosa injury
dc.subjectstomach protection
dc.subjectstomach ulcer
dc.subjecttissue regeneration
dc.subjecttoxicity testing
dc.subjectulcer healing
dc.subjectulcerogenesis
dc.titleEffects of the ethyl acetate fraction of Alchornea triplinervia on healing gastric ulcer in ratsen
dc.typeArtigo
dcterms.licensehttp://www.mdpi.com/about/openaccess
dspace.entity.typePublication
unesp.author.lattes2328604224911233[6]
unesp.author.lattes0019393779801069[7]
unesp.author.lattes3814504901386844[9]
unesp.author.orcid0000-0002-4198-0135[6]
unesp.author.orcid0000-0002-8645-3777[9]
unesp.author.orcid0000-0003-3032-2556[4]
unesp.author.orcid0000-0002-4494-4180[7]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.departmentFisiologia - IBBpt
unesp.departmentMorfologia - IBBpt

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